210150

Cantharidic Acid

A potent inhibitor of protein phosphatase 2A (IC₅₀ = 50 nM).

• Synonyme(s) : Cantharidic Acid, 5ʹ-3ʹ2,3-Dicarboxy-2,3-dimethyl-1,4-epoxycyclohexane, exo-1,6-Dicarboxy- endo-1,6-dimethyl-7-oxabicylco[2,2,1]heptane
• Formule empirique (notation de Hill): C₁₀H₁₄O₅
• Numéro CAS: 28874-45-5
• Poids moléculaire : 214.22
• Numéro MDL: MFCD00047137
• Code UNSPSC : 12352106
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: >95% (TLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: white
• Solubilité: warm ethanol: 10 mg/mL; DMSO: 25 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 10-30°C
• InChI: 1S/C10H14O5/c1-9(7(11)12)5-3-4-6(15-5)10(9,2)8(13)14/h5-6H,3-4H2,1-2H3,(H,11,12)(H,13,14)/t5-,6+,9-,10+
• Clé InChI: NMTNUQBORQILRK-YUMGAWCOSA-N

Description

Description générale

A potent inhibitor of protein phosphatase 2A (IC₅₀ = 50 nM).

Inhibits protein phosphatase 2A (IC₅₀ = 50 nM).

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
PP2A

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 50 nM against protein phosphatase 2A

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliqot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Zhang, Z., et al. 1996. Biochemistry35, 1606.
Li, Y.-M., and Casida, J.E. 1992. Proc. Natl. Acad. Sci. USA89, 11867.
Graziano, M.J., et al. 1988. Mol. Pharmacol.33, 706.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3