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Key Documents

COA/CoQ

14-251-M

p38α/SAPK2a Protein, active, 10 µg

Name: p38α/SAPK2a Protein, active, 10 µg
Brand: MM

Active, N-terminal GST tagged, recombinant, full length p38α/SAPK2a, for use in Kinase Assays.

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About This Item

Code UNSPSC :

12352200

eCl@ss :

32160405

Nomenclature NACRES :

NA.41

Source biologique

human

Niveau de qualité

100

Produit recombinant

expressed in E. coli

Poids mol.

M_w 67.7 kDa

Fabricant/nom de marque

Upstate^®

Technique(s)

activity assay: suitable (kinase)

Description générale

N-terminal GST tagged, recombinant, full length p38α/SAPK2a

Product Source: expressed in E. coli

Actions biochimiques/physiologiques

Protein Target: p38α/SAPK2a

Target Sub-Family: CMGC

Conditionnement

Also available in 250μg size (2x125μg) - Call for pricing and availability. Please reference catalog number 14-251M when ordering the 250μg size.

Qualité

Routinely evaluated by phosphorylation of MBP

Forme physique

Glutathione-agarose

Stockage et stabilité

6 months at -20°C

Autres remarques

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictogrammes

GHS07

Mention d'avertissement

Warning

Mentions de danger

H317

Conseils de prudence

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Classification des risques

Skin Sens. 1

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells.

Y N Doza et al.

FEBS letters, 364(2), 223-228 (1995-05-08)

A MAP kinase homologue, termed the reactivating kinase (RK), lies in a signalling pathway which mediates cellular responses to stress. Here we demonstrate that the stress-induced activation of the RK in human KB cells is accompanied by the phosphorylation of

A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway.

Ben-Levy, R, et al.

The Embo Journal, 13, 3302-3311 (1994)

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1.

A Cuenda et al.

FEBS letters, 364(2), 229-233 (1995-05-08)

A class of pyridinyl imidazoles inhibit the MAP kinase homologue, termed here reactivating kinase (RK) [Lee et al. (1994) Nature 372, 739-746]. We now show that one of these compounds (SB 203580) inhibits RK in vitro (IC50 = 0.6 microM)

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