119136

Adenosine A1 Receptor Agonist II, CCPA

• Synonyme(s) : Adenosine A1 Receptor Agonist II, CCPA
• Formule empirique (notation de Hill): C₁₅H₂₀ClN₅O₄
• Numéro CAS: 37739-05-2
• Poids moléculaire : 369.80
• Numéro MDL: MFCD00078574
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥99% (HPLC)
• Niveau de qualité: 100
• Forme: solid
• Puissance: 2.3 nM K_i
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: DMSO: 100 mM; water: 5 mM
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C15H20ClN5O4/c16-15-19-12(18-7-3-1-2-4-7)9-13(20-15)21(6-17-9)14-11(24)10(23)8(5-22)25-14/h6-8,10-11,14,22-24H,1-5H2,(H,18,19,20)/t8-,10-,11-,14-/m1/s1
• Clé InChI: XSMYYYQVWPZWIZ-IDTAVKCVSA-N

Description

Description générale

An adenosine analog that acts as a selective, high affinity agonist for Adenosine A1 receptor (A1R) (K_i = 800 pM; 2.3 µM, 18.8 µM, and 42 nM for human A1, A2A, A2B, A3 respectively). Shown to be centrally active following systemic administration and exhibits anti-convulsive effects. Also reported to inhibit adenylate cyclase activity in rat fat cell membrane (IC₅₀ = 33 nM). Diminishes respiratory rhythm, reduces heart rate, and enhances the activity of K_ATP channels. Reduces norepinephrine release by about 50% in untreated and pertussis toxin treated hearts.

Actions biochimiques/physiologiques

Primary Target
A1

Reversible: yes

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Burgdorf, C. et al. 2005. J Cardiovasc Pharmacol.45, 1.
Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
Mironov, S., et al. 1990. J Neurophysiol.81, 1.
Monopoli, A., et al. 1994.Arzneimittelforschung.44, 1305.
Concas, A., et al. 1993. J Pharmacol Exp Ther.267, 844.
Lohse, M. J., et al. 1988. Nauryn Schmiedebergs Arch Pharmacol.337, 687.
Coffin, V. L., et al. 1987. J Pharmacol Exp Ther.241, 76.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable