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Merck
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Principaux documents

07-1378

Sigma-Aldrich

Anti-QIK (SIK2) Antibody

Upstate®, from rabbit

Synonyme(s) :

Qin-induced kinase, SNF1-like kinase 2, Salt-inducible protein kinase 2, salt-inducible kinase 2, salt-inducible serine/threonine kinase 2

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Forme d'anticorps

purified antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Espèces réactives

rat, canine, mouse, chicken, bovine, human

Fabricant/nom de marque

Upstate®

Technique(s)

western blot: suitable

Numéro d'accès NCBI

NP_056006

Numéro d'accès UniProt

Q9H0K1

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... SIK2(23235)

Description générale

QIK (Qin-induced Kinase, SNF1LK2, SIK2, Salt-induced protein Kinase 2) is a Ser/Thr kinase that belongs to the AMPK/SNF1 kinase family. QIK is phosphorylated and activated by the tumor suppressor LKB1 when in complex with the pseudokinase STRAD and the scaffolding protein MO25. QIK has been found in adipocytes where it is known to phosphorylate a few substrates that include insulin receptor substrate 1 (IRS1) on Ser794 and TORC2 (also known as CRTC2 and not to be confused with the mTOR complex) on Ser171. The phosphorylation of TORC2 results in its translocation to the nucleus where it binds to CREB.

Spécificité

Close homology with mouse, rat, chicken, dog, and cow.
Detects QIK

Immunogène

KLH-conjugated synthetic peptide corresponding to the C-term of human QIK.

Application

Anti-QIK (SIK2) Antibody is an antibody against QIK (SIK2) for use in WB.
Research Category
Signaling

Qualité

Western Blot Analysis:
This lot detected QIK at 1:1,000-1:2,000 dilution in HeLa lysates via SDS-PAGE and transferred to PVDF (Immobilon-P).

Description de la cible

104 kDa

Forme physique

Format: Purified
Protein A purified
Protein A purified rabbit serum in 0.1M Tris-Glycine (pH7.4) 15mM NaCl, and 0.05% NaN3 with 30% glycerol.

Stockage et stabilité

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Remarque sur l'analyse

Control
HeLa Cell Lysate

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Salt-inducible kinase in steroidogenesis and adipogenesis.
Okamoto, Mitsuhiro, et al.
Trends in Endocrinology and Metabolism, 15, 21-26 (2004)

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