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Key Documents

05-643

Sigma-Aldrich

Anti-phospho-GSK3β (Ser9) Antibody, clone 2D3

clone 2D3, Upstate®, from mouse

Synonyme(s) :

Anti-7330414F15Rik, Anti-8430431H08Rik, Anti-C86142, Anti-GSK-3, Anti-GSK-3beta, Anti-GSK3

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

2D3, monoclonal

Espèces réactives

human, mouse, rat

Fabricant/nom de marque

Upstate®

Technique(s)

electrophoretic mobility shift assay: suitable
western blot: suitable

Isotype

IgG1κ

Numéro d'accès NCBI

NM_002093

Numéro d'accès UniProt

P49841

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

phosphorylation (pSer9)

Informations sur le gène

human ... GSK3B(2932)

Spécificité

GSK3beta

Immunogène

peptide corresponding to amino acids 6-12 (RTT[pS]AE) of human GSK3beta

Application

Anti-phospho-GSK3β (Ser9) Antibody, clone 2D3 is an antibody against phospho-GSK3β (Ser9) for use in EMSA & WB.
Research Category
Signaling
Research Sub Category
PI3K, Akt, & mTOR Signaling

Qualité

routinely evaluated by immunoblot on L6 cells stimulated with IGF-1

Description de la cible

46kDa (GSK3β) and 51kDa (GSK3α)

Liaison

Replaces: 04-1075

Forme physique

100µg of thiophilic and size exclusion chromatography purified mouse IgG1κ in 100µL of antibody storage buffer (PBS with PEG, Sucrose, and 0.09% sodium azide) and 50% glycerol.
Format: Purified
Thiophilic adsorption chromatography

Stockage et stabilité

2 years at -20°C

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

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Hui Sheng et al.
International journal of medical sciences, 10(6), 782-789 (2013-05-01)
We previously reported that the constitutional flavonoid glycosides derived from herb Epimedium (EF, composed of seven flavonoid compounds with common nuclear stem) exerted beneficial effects on the bone, including promoting bone formation and inhibiting bone marrow fat deposition. Recent in
Inhibition of cyclin-dependent kinase 5 but not of glycogen synthase kinase 3-? prevents neurite retraction and tau hyperphosphorylation caused by secretable products of human T-cell leukemia virus type I-infected lymphocytes.
Maldonado, H; Ramirez, E; Utreras, E; Pando, ME; Kettlun, AM; Chiong, M; Kulkarni et al.
Journal of Neuroscience Research null
Pei-Wen Cheng et al.
Biomedicines, 9(11) (2021-11-28)
Traumatic brain injury confers a significant and growing public health burden. It is a major environmental risk factor for dementia. Nonetheless, the mechanism by which primary mechanical injury leads to neurodegeneration and an increased risk of dementia-related diseases is unclear.
Yu-Te Lin et al.
Journal of clinical medicine, 7(10) (2018-10-12)
Recent studies have indicated that several anti-hypertensive drugs may delay the development and progression of Alzheimer's disease (AD). However, the relationships among AD, hypertension, and oxidative stress remain to be elucidated. Here, we aimed to determine whether reactive oxygen species
Adam R Cole et al.
Methods in molecular biology (Clifton, N.J.), 468, 45-65 (2008-12-23)
Glycogen synthase kinase (GSK)-3 is a key signalling intermediate in the action ofWnts. This protein kinase is ubiquitously expressed and has high inherent activity but is inhibited by activation of Wnt signalling or activation of growth factor receptor tyrosine kinases
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