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Merck
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Key Documents

05-1100-M

Sigma-Aldrich

Anti-Sulfotyrosine Antibody, Clone Sulfo-1C-A2

clone Sulfo-1C-A2, Upstate®, from mouse

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

Sulfo-1C-A2, monoclonal

Espèces réactives

human, mouse, bovine, porcine

Réactivité de l'espèce (prédite par homologie)

all

Fabricant/nom de marque

Upstate®

Technique(s)

ELISA: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotype

IgG2aκ

Description générale

Sulfotyrosine is a common post-translational modification of secretory, plasma membrane, and lysosomal proteins. The sulfation reaction is catalyzed by specific sulfotransferase enzymes in the trans-Golgi-network. Tyrosine sulfation occurs in all multicellular organisms and up to 1% of the tyrosines in the total protein content of a cell can be sulfated. Sulfotyrosines mediates many receptor-ligand binding interactions, including the interaction of P-selectin glycoprotein ligand-1 with P-selectin, factor VIII binding to von Willebrand factor, and interactions between thrombin and hirudin. Sulfotyrosine is also involved in the entry of several parasites and viruses; for example, tyrosine sulfation of the HIV-1 co-receptor CCR5 is required for viral entry into host cells, and tyrosine sulfation of the Duffy antigen/receptor for chemokines is crucial for erythrocyte invasion by the malaria parasite Plasmodium vivax.

This clone was derived from the antibody described in Kehoe et al., 2006.

Spécificité

The antibody is predicted to recognize any sulfotyrosine, regardless of surrounding amino acid sequence.

Application

Detect Sulfotyrosine with Anti-Sulfotyrosine Antibody, Clone Sulfo-1C-A2 (Mouse Monoclonal Antibody), that has been shown to work in WB, IP, ELISA.

Qualité

Assayed using sulfatase treated bovine fibrinogen vs. untreated fibrinogen.

Description de la cible

n/a

Forme physique

Format: Purified

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Yorihiro Nishimura et al.
PLoS pathogens, 6(11), e1001174-e1001174 (2010-11-17)
Enterovirus 71 (EV71) is one of the major causative agents of hand, foot, and mouth disease, a common febrile disease in children; however, EV71 has been also associated with various neurological diseases including fatal cases in large EV71 outbreaks particularly
Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum.
Friedman, James, et al.
Testing, 7, e37648-e37648 (2012)
Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1.
Pejchal, Robert, et al.
Proceedings of the National Academy of Sciences of the USA, 107, 11483-11488 (2010)
Juan Xu et al.
PloS one, 8(3), e56114-e56114 (2013-03-09)
The latent membrane protein 1 (LMP1), which is encoded by the Epstein-Barr virus (EBV), is an important oncogenic protein that is closely related to carcinogenesis and metastasis of nasopharyngeal carcinoma (NPC), a prevalent cancer in China. We previously reported that

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