IMPN-007-04

Naloxone N-oxide solution

100 μg/mL in acetonitrile: water (1:1), ampule of 1 mL, certified reference material, Cerilliant^®

• Synonyme(s) : Naloxone N-oxide solution
• Formule empirique (notation de Hill): C₁₉H₂₁NO₅
• Numéro CAS: 112242-14-5
• Poids moléculaire : 343.37
• Code UNSPSC : 41116107
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material
• Forme: liquid
• Caractéristiques: Snap-N-Spike^®/Snap-N-Shoot^®
• Conditionnement: ampule of 1 mL
• Fabricant/nom de marque: Cerilliant^®
• Concentration: 100 μg/mL in acetonitrile: water (1:1)
• Technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Application(s): forensics and toxicology
• Format: single component solution
• Température de stockage: −20°C
• Chaîne SMILES: Oc1ccc2C[C@@H]3[C@]4(O)CCC(=O)[C@@H]5Oc1c2[C@]45CC[N@@+]3([O-])CC=C
• InChI: 1S/C19H21NO5/c1-2-8-20(24)9-7-18-15-11-3-4-12(21)16(15)25-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-,20?/m1/s1
• Clé InChI: GAUIBVINJLVYRY-QBFPIVRFSA-N

Description

Description générale

Naloxone N-oxide is an impurity in pharmaceutical drug formulations of naloxone as well as a potential naloxone urinary metabolite. This certified solution standard is suitable for numerous LC or LC/MS applications from pharmaceutical testing and research to clinical toxicology or forensic analysis. Naloxone, sold under various trade names including Narcan^®, Nalone, and Narcanti, is an opiate drug used to counter the effects of opiate overdose such as those involving heroin or morphine.

Application

• Nociceptive Descending Inhibition Restoration: Naloxone N-oxide has been studied in the context of traumatic brain injury in rats, focusing on its role in restoring nociceptive descending inhibition through the periaqueductal gray. This application contributes to our understanding of opioid receptor antagonist research in the recovery of neurological functions (Irvine et al., 2024).


• Opioid Receptor Research: Research on Naloxone N-oxide involves exploring its interaction with opioid receptors, particularly in the context of stress-induced reinstatement of drug preferences. This underscores its importance in studies related to opioid receptor antagonist mechanisms in addiction and stress response (Nygard et al., 2016).


• Quantitative Biochemical Assays: The use of Naloxone N-oxide in liquid chromatography-tandem mass spectrometry assays exemplifies its role in the simultaneous quantification of buprenorphine, naloxone, and their metabolites. This is crucial for pharmacokinetic analysis and monitoring drug metabolism in clinical settings (Swortwood et al., 2016).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Narcan is a registered trademark of Endo Pharmaceuticals Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H225,H302,H319
• Conseils de prudence: P210 - P233 - P240 - P241 - P301 + P312 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 55.4 °F - closed cup
• Point d'éclair (°C): 13 °C - closed cup