H-134

Hydroxynorketamine hydrochloride solution

1.0 mg/mL in methanol (as free base), certified reference material, ampule of 1 mL, Cerilliant^®

• Formule empirique (notation de Hill): C₁₂H₁₄ClNO₂ · HCl
• Poids moléculaire : 276.16
• Code UNSPSC : 41116107
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material
• Niveau de qualité: 300
• Forme: liquid
• Caractéristiques: Snap-N-Spike^®/Snap-N-Shoot^®
• Conditionnement: ampule of 1 mL
• Fabricant/nom de marque: Cerilliant^®
• Concentration: 1.0 mg/mL in methanol (as free base)
• Technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Application(s): forensics and toxicology
• Format: single component solution
• Température de stockage: −20°C

Description

Description générale

Hydroxynorketamine (HNK), or 6-hydroxynorketamine, is a secondary metabolite of the anesthetic, dissociative, and antidepressant drug ketamine. It is formed by hydroxylation of the intermediate norketamine. This certified Snap-N-Spike^® solution is suitable for numerous GC/MS or LC/MS applications in forensic analysis, urine drug testing, clinical toxicology, and clinical or diagnostic testing. Ketamine, sold as Ketanest, Ketaset and Ketalar, is an NMDA receptor antagonist used for the induction and maintenance of general anesthesia in human and veterinary medicine. The drug is often abused at clubs, raves, or parties for its noted hallucingenic and dissociative properties and prescribed by some doctors as an off-label treatment for depression.

Application

• Hydroxynorketamine HCl for neuropharmacological research: Hydroxynorketamine hydrochloride, a novel NMDA receptor modulator, has shown potential in enhancing synaptic plasticity. This compound provides a promising avenue for exploring neuroprotective strategies in neuropharmacological studies (Fountoulakis et al., 2023).
• Antidepressant effects of Hydroxynorketamine HCl in preclinical studies: Studies have demonstrated that Hydroxynorketamine hydrochloride exhibits significant antidepressant effects, making it a valuable candidate for treatment-resistant depression research. This compound′s unique mechanism involving the NMDA receptor highlights its potential in psychiatric treatments (Gilbert et al., 2021).
• Synaptic plasticity research using Hydroxynorketamine hydrochloride: Hydroxynorketamine hydrochloride′s role in modulating synaptic plasticity has been studied, emphasizing its therapeutic potential in neurodegenerative diseases and cognitive disorders. This research underlines the importance of Hydroxynorketamine as a tool in understanding the complexities of synaptic functions (Evans et al., 2018).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H225,H301 + H311 + H331,H370
• Conseils de prudence: P210 - P260 - P280 - P301 + P310 + P330 - P308 + P311 - P370 + P378 - P403 + P233
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 49.5 °F - closed cup
• Point d'éclair (°C): 9.7 °C - closed cup