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D-062

Supelco

21-Deoxycortisol solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Formule empirique (notation de Hill):
C21H30O4
Numéro CAS:
641-77-0
Poids moléculaire :
346.46
Numéro CE :
200-659-6
Numéro MDL:
MFCD00056476
Code UNSPSC :
41116107
ID de substance PubChem :
329798625
Nomenclature NACRES :
NA.24

Qualité

certified reference material

Niveau de qualité

300

Forme

liquid

Caractéristiques

Snap-N-Spike®/Snap-N-Shoot®

Conditionnement

ampule of 1 mL

Fabricant/nom de marque

Cerilliant®

Concentration

100 μg/mL in methanol

Technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Application(s)

clinical testing
clinical testing

Format

single component solution

Température de stockage

−20°C

Chaîne SMILES 

CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C

InChI

1S/C21H30O4/c1-12(22)21(25)9-7-16-15-5-4-13-10-14(23)6-8-19(13,2)18(15)17(24)11-20(16,21)3/h10,15-18,24-25H,4-9,11H2,1-3H3/t15-,16-,17-,18+,19-,20-,21-/m0/s1

Clé InChI

LCZBQMKVFQNSJR-UJPCIWJBSA-N

Description générale

A new calibration material suitable for LC/MS applications in clinical and diagnostic testing and endocrinology. 21-deoxycortisol, a steroid intermediate in the formation of cortisol, is measured in whole blood or serum by LC/MS for newborn screening of congenital adrenal hyperplasia (CAH) and other adrenal diseases.

Application

  • Steroid profiling for the diagnosis of congenital adrenal hyperplasia by microbore ultra-performance liquid chromatography-tandem mass spectrometry: This article emphasizes the significance of steroid profiling using advanced chromatography techniques to diagnose congenital adrenal hyperplasia, highlighting the role of 21-Deoxycortisol as a critical marker (Feng D et al., 2023).
  • Second-tier Testing for 21-Hydroxylase Deficiency in the Netherlands: A Newborn Screening Pilot Study: This study introduces a second-tier testing protocol involving 21-Deoxycortisol to enhance the screening process for congenital adrenal hyperplasia in newborns, demonstrating its utility in early and accurate diagnosis (Stroek K et al., 2021).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

A-096

Aldosterone solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

C-106

Cortisol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

C-113

Cortisol-D4 (9,11,12, 12-D4) solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

C-117

Corticosterone solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

D-061

11-Deoxycortisol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

D-076

21-Deoxycortisol-d8 (2,2,4,6,6,21,21,21-d8), 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

D-078

11-Deoxycortisol-D5 (2,2,4,6,6-D5), 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

D-085

Dexamethasone solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-085

17α-Hydroxyprogesterone solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-096

17α-Hydroxyprogesterone-d8 (2,2,4,6,6,21,21,21-d8), 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-100

17α-Hydroxyprogesterone-2,3,4-13C3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

P-069

Progesterone solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

P-070

Progesterone-D9 solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

C-160

Cortisone-13C3 solution, 100 μg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant®

C-159

Corticosterone-13C3 solution, 10 μg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant®

C-216

Cortisol-13C3 solution, 100 μg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant®

P-123

Prednisolone-13C3 solution, 100 μg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant®

P-124

Prednisone-13C3 solution, 100 μg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant®

Pictogrammes

FlameSkull and crossbonesHealth hazard
GHS02,GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Organes cibles

Eyes

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

49.5 °F - closed cup

Point d'éclair (°C)

9.7 °C - closed cup

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

A Milewicz et al.
Endokrynologia Polska, 44(2), 187-193 (1993-01-01)
The study was aimed at evaluation of usefulness of determination of blood serum 21-deoxycortisol concentration for the detection of heterozygous carriers of incomplete block of 21-hydroxylase synthesis leading to adrenal hyperplasia. An earlier observation of the authors that the determination
[21-Deoxycortisol].
Y Okatani
Nihon rinsho. Japanese journal of clinical medicine, 53 Su Pt 2, 444-447 (1995-03-01)
H Blanché et al.
Human genetics, 101(1), 56-60 (1998-01-07)
21-hydroxylase (21-OH) deficiency accounts for the vast majority of nonclassic (NC) forms of congenital adrenal hyperplasia (CAH), and is associated with symptoms detectable either in childhood (precocious puberty) or sometimes only later in adulthood (hirsutism, acne, amenorrhea). While the severe
Simone Cristoni et al.
Rapid communications in mass spectrometry : RCM, 18(1), 77-82 (2003-12-23)
Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder mainly caused by 21-hydroxylase deficit (21-OHD). Deletions or mutations of the CYP21 gene induce the impairment of glucocorticoid and mineralcorticoid synthesis. 17-Hydroxyprogesterone (17-OHP) is the hormonal marker in patients, but not
N S Sieber-Ruckstuhl et al.
The Veterinary record, 162(21), 673-678 (2008-05-27)
The serum concentrations of cortisol, 17alpha-hydroxypregnenolone, 17alpha-hydroxyprogesterone, 21-deoxycortisol and 11-deoxycortisol were measured in 19 healthy dogs, 15 dogs with pituitary-dependent hypercortisolism (pdh) and eight dogs with other diseases before and one hour after an injection of synthetic adrenocorticotrophic hormone (acth).
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