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A77806

4-Aminopyrazolo[3,4-d]pyrimidine

Name: 4-Aminopyrazolo[3,4-<I>d</I>]pyrimidine
Brand: ALDRICH

98%

Synonyme(s) :

1H-Pyrazolo[3,4-d]pyrimidine-4-ylamine, 4-Amino-1H-pyrazolo[3,4-d]pyrimidine

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About This Item

Formule empirique (notation de Hill):

C₅H₅N₅

Numéro CAS:

2380-63-4

Poids moléculaire :

135.13

Numéro CE :

219-174-6

Numéro MDL:

MFCD00005688

Code UNSPSC :

12352100

ID de substance PubChem :

24891277

Nomenclature NACRES :

NA.22

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Sigma-Aldrich

P5504

Phosphate de potassium dibasic trihydrate

Pureté

98%

Forme

powder

Pf

>325 °C (lit.)

Chaîne SMILES

Nc1ncnc2[nH]ncc12

InChI

1S/C5H5N5/c6-4-3-1-9-10-5(3)8-2-7-4/h1-2H,(H3,6,7,8,9,10)

Clé InChI

LHCPRYRLDOSKHK-UHFFFAOYSA-N

Application

Decreases serum cholesterol markedly in rats.

Pictogrammes

GHS06

Mention d'avertissement

Danger

Mentions de danger

H301,H315,H319,H335

Conseils de prudence

P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338

Classification des risques

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificats d'analyse (COA)

Lot/Batch Number

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Gonadotropin modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in desensitized luteinized rat ovary.

S Azhar et al.

Biochemistry, 23(20), 4533-4538 (1984-09-25)

These studies were done to examine the effect of gonadotropin on rat luteal 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase activity (the rate-limiting step in cholesterol biosynthesis) in ovaries of pregnant mare's serum gonadotropin (PMSG)-human chorionic gonadotropin (hCG) primed rats. Administration

Effect of hypocholesterolemic doses of 17 alpha-ethinyl estradiol on cholesterol balance in liver and extrahepatic tissues.

M Bertolotti et al.

Journal of lipid research, 37(8), 1812-1822 (1996-08-01)

This study was performed to investigate the effects of 17 alpha-ethinyl estradiol, a potent hypocholesterolemic agent at pharmacological doses, on cholesterol balance in the liver and extrahepatic tissues of the rat in vivo. Female Sprague-Dawley rats were treated with 17

Ovarian vitamin E accumulation: evidence for a role of lipoproteins.

R F Aten et al.

Endocrinology, 135(2), 533-539 (1994-08-01)

Reactive oxygen species, such as superoxide, hydrogen peroxide, and lipid peroxides, impair luteal function. Vitamin E, a lipophilic antioxidant vitamin, provides a major avenue of protection by scavenging free radicals and terminating lipid peroxidation. We previously showed that ovarian vitamin

Influence of altered serum cholesterol levels and fasting on cutaneous cholesterol synthesis.

S Wu-Pong et al.

The Journal of investigative dermatology, 102(5), 799-802 (1994-05-01)

Barrier perturbation stimulates epidermal cholesterol synthesis, which plays an important role in restoring barrier function. In the present study, we examined whether changes in serum cholesterol levels or nutrition regulate epidermal cholesterol synthesis in hairless mice. Serum cholesterol levels were

Cholesterol synthesis in regenerating peripheral nerve is not influenced by serum cholesterol levels.

J F Goodrum

Journal of neurochemistry, 60(4), 1564-1566 (1993-04-01)

Following a nerve crush, cholesterol from degenerating myelin is retained within the nerve and reutilized for new myelin synthesis during nerve regeneration, apparently via a lipoprotein-mediated process. Because at least some serum components have access to the endoneurium of injured

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