936618

(S,R,S)-AHPC-CO-PEG4-C2-amine HCl

≥95%

• Synonyme(s) : (2S,4R)-1-((S)-1-amino-17-(tert-butyl)-15-oxo-3,6,9,12-tetraoxa-16-azaoctadecan-18-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, (2S,4R)-1-[(2S)-2-(1-amino-3,6,9,12-tetraoxapentadecan-15-amido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide hydrochloride
• Formule empirique (notation de Hill): C₃₃H₅₁N₅O₈S · xHCl
• Numéro CAS: 2376139-48-7
• Poids moléculaire : 677.85 (free base basis)
• Code UNSPSC : 12352106
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95%
• Forme: crystals (or crystals with chunks)
• Couleur: White to Light Yellow
• Température de stockage: 2-8°C
• Chaîne SMILES: C([C@@H](NC(CCOCCOCCOCCOCCN)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1.Cl

Description

Application

(S,R,S)-AHPC-CO-PEG4-C2-amine HCl is a functionalized functionalized von Hippel-Lindau (VHL) ligand. It contains a terminal amine for conjugation with carboxylic acid linkers. A basic building block for development of a protein degrader library.


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Autres remarques

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable