936472

(S,R,S)-AHPC-pentanoic-acid

≥95%

• Synonyme(s) : 6-[[(1S)-1-[[(2S,4R)-4-Hydroxy-2-[[[4-(4-methylthiazol-5-yl)phenyl]methyl]carbamoyl]pyrrolidin-1-yl]carbonyl]-2,2-dimethylpropyl]amino]-6-oxohexanoic acid, 6-[[(S)-1-[(2S,4R)-4-Hydroxy-2-[[4-(4-methylthiazol-5-yl)benzyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-6-oxohexanoic acid, L-Prolinamide, N-(5-carboxy-1-oxopentyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
• Formule empirique (notation de Hill): C₂₈H₃₈N₄O₆S
• Numéro CAS: 2172819-74-6
• Poids moléculaire : 558.69
• Numéro MDL: MFCD32693310
• Code UNSPSC : 12352106
• Nomenclature NACRES : NA.22

Propriétés

• ligand: VH032
• Niveau de qualité: 100
• Pureté: ≥95%
• Forme: powder
• Couleur: white to light yellow
• Température de stockage: 2-8°C
• Chaîne SMILES: C([C@@H](NC(CCCCC(O)=O)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1

Description

Application

(S, R, S)-AHPC-pentanoic-acid is a functionalized von Hippel-Lindau (VHL) ligand. It contains a terminal carboxyl group for conjugation with amine linkers. A basic building block for development of a protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks

Autres remarques

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Informations légales

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable