934283

4-(Aminoethyl)-1-N-Boc-piperidine

≥95.0%

• Synonyme(s) : 1-tert-Butoxycarbonyl-4-piperidineethanamine, 2-(N-tert-Butoxycarbonyl-4-piperidinyl)ethylamine
• Formule empirique (notation de Hill) : C₁₂H₂₄N₂O₂
• Numéro CAS: 146093-46-1
• Poids moléculaire : 228.33
• Numéro MDL: MFCD04038459
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.21

Propriétés

• Niveau de qualité: 100
• Essai: ≥95.0%
• Forme: semisolid
• Couleur: off-white to light yellow
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C(OC(C)(C)C)N1CCC(CCN)CC1
• InChI: 1S/C12H24N2O2/c1-12(2,3)16-11(15)14-8-5-10(4-7-13)6-9-14/h10H,4-9,13H2,1-3H3
• Clé InChI: LBQDLHPFISVBRU-UHFFFAOYSA-N

Description

Application

A semi-flexible linker useful for PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of PROTACs may impact degradation kinetics as well as drug design (absorption; distribution; metabolism; excretion; and toxicity; ADMET) properties of PROTACs.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Autres remarques

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Informations légales

PROTAC^® is a registered trademark of Arvinas Operations; Inc.; and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable