933090
NanoFabTx™ NanoFlash PEG-PCL drug formulation screening kit
for CIJ synthesis of nanoparticles
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About This Item
Produits recommandés
Température de stockage
2-8°C
Application
NanoFabTx™ NanoFlash PEG-PCL drug formulation screening kit is a ready to use nanoformulation kit for flash nanoprecipitation synthesis of PEGylated poly(caprolactone) (PCL) nanoparticles for drug delivery research applications. This kit contains rationally selected PEGylated PCL polymers and stabilizer, enabling users to screen and select nanoformulations without the need for lenghty trial and error optimization. These PEGylated PCL polymers have been widely used in drug delivery systems for controlled drug release of many different types of therapeutic molecules.
This kit has been curated and designed for flash nanoprecipitiaton (FNP) nanoparticle synthesis using a confined impingement jet (CIJ) mixer, such as the NanoFabTx™ NanoFlash CIJ Mixer, and detailed step-by-step instructions are provided.
This kit has been curated and designed for flash nanoprecipitiaton (FNP) nanoparticle synthesis using a confined impingement jet (CIJ) mixer, such as the NanoFabTx™ NanoFlash CIJ Mixer, and detailed step-by-step instructions are provided.
Caractéristiques et avantages
- Ready-to-use nanoformulation kit for PEGylated nanoparticles
- Step-by-step flash nanoprecipitation protocol
- Create specifically sized, biodegradable, PEGylated PCL nanoparticles
- Maximize the encapsulation of hydrophobic drugs
- Three different PEGylated PCL polymers are included
- Optimized for 60 nm-150 nm nanoparticles
Informations légales
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Journal of pharmaceutical sciences, 101(10), 4018-4023 (2012-07-11)
Johnson and Prud'homme (2003. AICHE J 49:2264-2282) introduced the confined impingement jets (CIJ) mixer to prepare nanoparticles loaded with hydrophobic compounds (e.g., drugs, inks, fragrances, or pheromones) via flash nanoprecipitation (FNP). We have modified the original CIJ design to allow
Macromolecular bioscience, 7(6), 767-783 (2007-06-02)
The controlled release of medicaments remains the most convenient way of drug delivery. Therefore, a wide variety of reports can be found in the open literature dealing with drug delivery systems. In particular, the use of nano- and microparticles devices
Chemical Society reviews, 41(7), 2971-3010 (2012-03-06)
Polymeric materials have been used in a range of pharmaceutical and biotechnology products for more than 40 years. These materials have evolved from their earlier use as biodegradable products such as resorbable sutures, orthopaedic implants, macroscale and microscale drug delivery
Advanced drug delivery reviews, 107, 176-191 (2016-06-06)
Poly(d,l-lactic acid) (PLA) has been widely used for various biomedical applications for its biodegradable, biocompatible, and nontoxic properties. Various methods, such as emulsion, salting out, and precipitation, have been used to make better PLA micro- and nano-particle formulations. They are
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
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