904740

Amine-poly(ethylene glycol)-b-poly(ε-caprolactone)

PEG average M_n 5,000, PCL average M_n 5,000

• Synonyme(s) : Amine PEG-PCL diblock copolymer, Carboxylic acid-PEG-PCL, PEG-b-PCL, PEG-PCL
• Formule linéaire : C₅H₁₂NOS[C₂H₄O]_n[C₆H₁₀O₂]_mH
• Code UNSPSC : 12352116

Propriétés

• Forme: powder or solid
• Poids mol.: PCL average M_n 5,000; PEG average M_n 5,000
• Couleur: white to off-white
• PDI: ≤1.3 (by GPC)
• Température de stockage: −20°C

Description

Application

Amine-poly(ethylene glycol)-b-poly(ε-caprolactone) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters. The amine functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable