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901376

Sigma-Aldrich

Polyester bis-MPA dendron

no. Surface Groups 8, 8 acetylene, 1 NHBoc (core), generation 3

Synonyme(s) :

PFd-G3-BOCNH-Acetylene, bis-MPA dendron

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About This Item

Formule empirique (notation de Hill):
C107H135NO53
Poids moléculaire :
2283.19
Code UNSPSC :
12162002
Nomenclature NACRES :
NA.23

Niveau de qualité

100

Forme

solid

Poids mol.

generation 3

Nb de groupes de surface

8

Couleur

white to off-white

Température de stockage

−20°C

Catégories apparentées

Description générale

  • Polymer architecture: Dendron
  • Generation: 3
  • Core functional group: Boc-protected amine
  • End Group Functionality: Alkyne
  • No. Surface Groups: 8
  • Calculated Mol. Wt.: 2283.21 g/mol
  • Boc : tert-Butyloxycarbonyl
  • bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid
Polyester bis-MPA dendron (8 acetylene, 1 NHBoc (core), generation 3), a high generation dendron, is synthesized by using anhydride activated bis-MPA monomers via divergent growth. It has a large and exact number of reactive groups and has dual functionalization capacity that makes it useful as a high-value scaffold.

Application

Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. These alkyne-functionalized dendrimers can be readily functionalized using either copper(I)-catalysed alkyne-azide cycloaddition (CuAAC), strain-promoted alkyne-azide cycloaddition (SPAAC), or thiol-yne click reactions. Additionally, the amine-functionalized core can be readily used in EDC or DCC coupling reactions (after Boc deprotection) with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

Articles

The Potential of Dendritic Polyester Scaffolds as Biocompatible Drug Delivery Agents

Professor Michael Malkoch provides an overview of the unique properties of dendritic molecules and their application in biomedical fields. He highlights bis-MPA dendritic scaffolds as a promising biodegradable and biocompatible platform for drug delivery applications

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

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