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739669

Sigma-Aldrich

25-Hydroxyvitamin D3 solution

5 μg/mL in ethanol, 98% (CP)

Synonyme(s) :

25-Hydroxycholecalciferol solution

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About This Item

Formule empirique (notation de Hill):
C27H44O2
Numéro CAS:
19356-17-3
Poids moléculaire :
400.64
Numéro CE :
200-578-6
Numéro MDL:
MFCD00867077
Code UNSPSC :
12352205
ID de substance PubChem :
329765369
Nomenclature NACRES :
NA.24

Pureté

98% (CP)

Forme

solution

Concentration

5 μg/mL in ethanol

Technique(s)

mass spectrometry (MS): suitable

Couleur

colorless

Application(s)

detection

Température de stockage

−20°C

Chaîne SMILES 

C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C

InChI

1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1

Clé InChI

JWUBBDSIWDLEOM-DTOXIADCSA-N

Informations sur le gène

human ... VDR(7421)

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Description générale

25-Hydroxyvitamin D3 (calcifediol) is a prohormone produced via hydroxylation of vitamin D3 (cholecalciferol) in the liver. It is a precursor for the synthesis of calcitriol {1,25-dihydroxyvitamin D3 or [1,25(OH)2D3]}. It is also used as a biomarker to determine the status of vitamin D in the body.

Application

This product may be used as an analytical standard.

Conditionnement

1 mL in ampule

Pictogrammes

FlameExclamation mark
GHS02,GHS07

Mention d'avertissement

Danger

Mentions de danger

H225,H319

Classification des risques

Eye Irrit. 2 - Flam. Liq. 2

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

57.2 °F

Point d'éclair (°C)

14.0 °C

Certificats d'analyse (COA)

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Alberto Lo Gullo et al.
PloS one, 10(8), e0134602-e0134602 (2015-08-05)
Suboptimal vitamin D status was recently acknowledged as an independent predictor of cardiovascular diseases and all-cause mortality in several clinical settings, and its serum levels are commonly reduced in Rheumatoid Arthritis (RA). Patients affected by RA present accelerated atherosclerosis and
Peter Daley et al.
The Lancet. Infectious diseases, 15(5), 528-534 (2015-04-13)
Vitamin D has immunomodulatory effects that might aid clearance of mycobacterial infection. We aimed to assess whether vitamin D supplementation would reduce time to sputum culture conversion in patients with active tuberculosis. We did this randomised, double-blind, placebo-controlled, superiority trial
Marina V Antunes et al.
Therapeutic drug monitoring, 37(6), 733-744 (2015-04-09)
In view of the large variability on therapeutic response and the multiple factors associated to tamoxifen (TAM) metabolic activation, this study aimed to evaluate the effect of CYP2D6 and CYP3A4 phenotypes, drug interactions, and vitamin D exposure on TAM metabolism
Fadia S AlBuhairan et al.
The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 57(3), 263-269 (2015-08-25)
With the increasing burden of noncommunicable disease, adolescence is viewed as an opportune time to prevent the onset of certain behaviors and promote healthy states. Although adolescents comprise a considerable portion of Saudi Arabia's population, they have received insufficient attention
Stuart M Sprague et al.
American journal of nephrology, 40(6), 535-545 (2015-01-13)
Vitamin D insufficiency drives secondary hyperparathyroidism (SHPT) and is associated with increased cardiovascular mortality in patients with chronic kidney disease (CKD). SHPT is poorly addressed by current vitamin D repletion options. The present study evaluated a novel investigational vitamin D
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