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Merck

RPS6KB1

ribosomal protein S6 kinase, 70kDa, polypeptide 1

Synonymes:
PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha
Espèce(s):
Human RPS6KB1 (6198), Mouse Rps6kb1 (72508), Rat Rps6kb1 (83840), chicken RPS6KB1 (417637), domestic cat RPS6KB1 (101092561), Horse RPS6KB1 (100057481), dog RPS6KB1 (480580), cow RPS6KB1 (404181), sheep RPS6KB1 (101107371), domestic guinea pig Rps6kb1 (100727216) ...Plus
ID UniProtKB:
P23443
ID du gène:
  • Human(6198) Summary: This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]
  • Mouse(72508) ribosomal protein S6 kinase, polypeptide 1
  • Rat(83840) ribosomal protein S6 kinase, polypeptide 1
  • chicken(417637) ribosomal protein S6 kinase, 70kDa, polypeptide 1
  • domestic cat(101092561) ribosomal protein S6 kinase, 70kDa, polypeptide 1
  • Horse(100057481) ribosomal protein S6 kinase, 70kDa, polypeptide 1
  • dog(480580) ribosomal protein S6 kinase, 70kDa, polypeptide 1
  • cow(404181) ribosomal protein S6 kinase, 70kDa, polypeptide 1
  • sheep(101107371) ribosomal protein S6 kinase, 70kDa, polypeptide 1
  • domestic guinea pig(100727216) ribosomal protein S6 kinase, 70kDa, polypeptide 1
  • naked mole-rat(101724077) ribosomal protein S6 kinase, 70kDa, polypeptide 1
  • Domestic Rabbit(100009260) ribosomal protein S6 kinase, 70kDa, polypeptide 1

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Antibodies

Référence du produit
Description
Espèces réactives
Application
MABS82
Anti-phospho-p70 S6 Kinase (Thr389) Antibody, clone 10G7.1, clone 10G7.1, from mouse,
Espèces réactives
human, mouse
Application
immunocytochemistry
western blot
07-018-I
Anticorps anti-phospho-p70 S6 kinase (Thr389), from rabbit, purified by affinity chromatography,
Espèces réactives
bovine, chicken, human, mouse, rat, zebrafish
Application
inhibition assay
western blot
SAB4502691
Anti-S6K antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
SAB4301471
Anti-phospho-p70 S6 Kinase (pThr389/412) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
western blot
SAB4503957
Anti-phospho-p70 S6 Kinase (pThr389) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
PZ0143
PF-4708671, ≥98% (HPLC),
Espèce(s)
human, mouse, rat

Proteins

Référence du produit
Description
Espèce(s)
P0066
p70S6K, active, His tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
human
14-486-M
p70 S6 Kinase Protein, active, 10 µg, Active, N-terminal His6-tagged, recombinant amino acids 1-421 of human p70 S6 kinase, for use in Kinase Assays.,
Espèce(s)
human
SRP0365
p70S6K active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE),
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
EHU107461
MISSION® esiRNA, targeting human RPS6KB1,
Espèce(s)
human