NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Synonymes:
GCCR, GCR, GR, GRL
Espèce(s):
Human NR3C1 (2908), Mouse Nr3c1 (14815), Rat Nr3c1 (24413), Zebrafish nr3c1 (553740), chicken NR3C1 (416343), dog NR3C1 (478047), domestic cat NR3C1 (692348), cow NR3C1 (281946), Horse NR3C1 (100061217), domestic cat NR3C1 (101080939) ...Plus
ID UniProtKB:
ID du gène:
- Human(2908) Summary: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
- Mouse(14815) nuclear receptor subfamily 3, group C, member 1
- Rat(24413) nuclear receptor subfamily 3, group C, member 1
- Zebrafish(553740) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- chicken(416343) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- dog(478047) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- domestic cat(692348) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- cow(281946) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- Horse(100061217) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- domestic cat(101080939) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- domestic guinea pig(100135583) nuclear receptor subfamily 3, group C, member 1
- naked mole-rat(101722101) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- Domestic Rabbit(100008890) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- sheep(443412) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
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Small Molecule - Activator
Small Molecule - Agonist
Référence du produit
Description
Espèce(s)
Cortisol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
Hydrocortisone 21-hemisuccinate sodium salt, powder, BioReagent, suitable for cell culture,
Espèce(s)
human
Small Molecule - Antagonist
Référence du produit
Description
Espèce(s)
Antibodies
Référence du produit
Description
Espèces réactives
Application
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Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
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Espèces réactives
human
Application
immunofluorescence
western blot
western blot
Anti-phospho-Glucocorticoid receptor Antibody, Ser226, from rabbit, purified by affinity chromatography,
Espèces réactives
human, mouse, rat
Application
western blot
Anti-Glucocorticoid Receptor Antibody, serum, from rabbit,
Espèces réactives
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Application
affinity binding assay
western blot
western blot
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Espèces réactives
guinea pig, mouse, rabbit, rat, sheep
Application
Small Molecule - Mixed Agonist/Antagonist
Référence du produit
Description
Espèce(s)
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Espèce(s)
mouse, rat, human