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Merck

GABBR2

gamma-aminobutyric acid (GABA) B receptor, 2

Synonymes:
GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(9568) Summary: The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]
  • Mouse(242425) gamma-aminobutyric acid (GABA) B receptor, 2
  • Rat(83633) gamma-aminobutyric acid (GABA) B receptor 2
  • Zebrafish(560267) gamma-aminobutyric acid (GABA) B receptor, 2
  • dog(481627) gamma-aminobutyric acid (GABA) B receptor, 2
  • Horse(100063963) gamma-aminobutyric acid (GABA) B receptor, 2
  • cow(517040) gamma-aminobutyric acid (GABA) B receptor, 2
  • domestic cat(101093058) gamma-aminobutyric acid (GABA) B receptor, 2
  • chicken(420979) gamma-aminobutyric acid (GABA) B receptor, 2
  • domestic guinea pig(100170764) gamma-aminobutyric acid (GABA) B receptor, 2
  • naked mole-rat(101719923) gamma-aminobutyric acid (GABA) B receptor, 2
  • sheep(101103544) gamma-aminobutyric acid (GABA) B receptor, 2
  • Domestic Rabbit(100346845) gamma-aminobutyric acid (GABA) B receptor, 2

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Small Molecule - Agonist

Référence du produit
Description
Espèce(s)
Baclofen, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Baclofen solution, 500 μg/mL (90:10 MeOH:DMSO), certified reference material, ampule of 1 mL, Cerilliant®,
Espèce(s)
human
Baclofen, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
Baclofen, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human
Baclofen, British Pharmacopoeia (BP) Reference Standard,
Espèce(s)
human

Small Molecule - Allosteric Modulator

Référence du produit
Description
Espèce(s)
CGP-13501, ≥98% (HPLC), solid,
Espèce(s)
human

Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
Phaclofen, solid,
Espèce(s)
human
2-Hydroxysaclofen, ≥98% (TLC), solid,
Espèce(s)
human
(±)-Baclofen, ≥98% (HPLC), solid,
Espèce(s)
human, rat
Saclofen, solid,
Espèce(s)
mouse, human, rat
γ-Aminobutyric acid, ≥99%,
Espèce(s)
human, rat

Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-GABA B Receptor R2 Antibody, serum, from guinea pig,
Espèces réactives
bovine, canine, chimpanzee, horse, human, mouse, rat, rhesus macaque, rhesus monkey
Application
immunohistochemistry
western blot
Anti-GABAB Receptor 2 antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Espèces réactives
rat
Application
western blot
Anti-GABBR2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-GABBR2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Monoclonal Anti-Gaba-B Receptor 2 - Atto 390 antibody produced in mouse, clone S81-2, purified immunoglobulin,
Espèces réactives
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry

western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
NO-711 hydrochloride, ≥98% (HPLC),
Espèce(s)
human
(±)-Vigabatrin, ,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human GABBR2,
Espèce(s)
human