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Merck

CHRM1

cholinergic receptor, muscarinic 1

Synonymes:
HM1, M1, M1R
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(1128) Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]
  • Mouse(12669) cholinergic receptor, muscarinic 1, CNS
  • Rat(25229) cholinergic receptor, muscarinic 1
  • cow(281684) cholinergic receptor, muscarinic 1
  • Horse(100064117) cholinergic receptor, muscarinic 1
  • domestic cat(101093801) cholinergic receptor, muscarinic 1
  • domestic cat(493664) cholinergic receptor, muscarinic 1
  • dog(483776) cholinergic receptor, muscarinic 1
  • naked mole-rat(101702102) cholinergic receptor, muscarinic 1
  • domestic guinea pig(100728041) cholinergic receptor, muscarinic 1
  • sheep(101117029) cholinergic receptor, muscarinic 1

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Small Molecule - Agonist

Product Number
Description
Espèce(s)
Pilocarpine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
Pilocarpine hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Pilocarpine nitrate, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Pilocarpine hydrochloride, phyproof® Reference Substance,
Espèce(s)
human
Pilocarpine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human

Small Molecule - Antagonist

Product Number
Description
Espèce(s)
Quinuclidine, 97%,
Espèce(s)
rat
Ethopropazine hydrochloride, ≥98% (HPLC), powder,
Espèce(s)
human
Scopolamine Hydrobromide, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
Benztropine mesylate, ≥98% (HPLC),
Espèce(s)
human
Pirenzepine dihydrochloride, ≥98% (TLC), powder,
Espèce(s)
human

Antibodies

Product Number
Description
Espèces réactives
Application
Anti-Muscarinic Acetylcholine Receptor m1 Antibody, Chemicon®, from rabbit,
Espèces réactives
mouse, rat
Application
immunohistochemistry
western blot
Anti-CHRM1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-CHRM1 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
western blot
Anti-Muscarinic Acetylcholine Receptor (M1) antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Espèces réactives
mouse, rat
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Espèce(s)
(+)-Pentazocine, solid,
Espèce(s)
rat, human
Amitriptyline hydrochloride, ≥98% (TLC), powder,
Espèce(s)
human
Cocaine free base, ,
Espèce(s)
mouse, rat, human
Doxepin hydrochloride, ~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder,
Espèce(s)
human
Haloperidol, powder,
Espèce(s)
human, rat

Small Molecule - Ligand

Product Number
Description
Espèce(s)
Aminobenztropine, solid,
Espèce(s)
human
Cocaine free base, ,
Espèce(s)
mouse, rat, human

Proteins

Product Number
Description
Espèce(s)
ChemiScreen Membrane Preparation Human Recombinant M1 Muscarinic Acetylcholine Receptor, Human M1 GPCR membrane prepation for Radioligand binding Assays.,
Espèce(s)
human

esiRNA

Product Number
Description
Espèce(s)
MISSION® esiRNA, targeting human CHRM1,
Espèce(s)
human