T3397

Tylosin solution

8 mg/mL in 0.9% NaCl, 0.1 μm filtered, BioReagent, suitable for cell culture

• CAS Number: 74610-55-2
• MDL number: MFCD07783824
• UNSPSC Code: 12352207
• PubChem Substance ID: 329826751
• NACRES: NA.76

Properties

• Quality Level: 200
• sterility: 0.1 μm filtered
• product line: BioReagent
• form: solution
• storage condition: (Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and keep upright to prevent leakage.)
• concentration: 8 mg/mL in 0.9% NaCl
• technique(s): cell culture | mammalian: suitable
• impurities: endotoxin, tested
• color: colorless to yellow
• antibiotic activity spectrum: Gram-positive bacteria; mycoplasma
• Mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: O[C@H]([C@@H](O)C(O)=O)C(O)=O.CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](CC=O)C[C@@H](C)C(=O)\C=C\C(C)=C\[C@@H]1CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC
• InChI: 1S/C46H77NO17.C4H6O6/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35;5-1(3(7)8)2(6)4(9)10/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3;1-2,5-6H,(H,7,8)(H,9,10)/b15-14+,23-18+;/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-;1-,2-/m11/s1
• InChI key: ICVKYYINQHWDLM-KBEWXLTPSA-N

Description

General description

Chemical structure: macrolide

Tylosin is a macrolide antibiotic, which comprises of a 16-member lactone ring. This solution is recommended for use at 1 mL/L.

Application

Tylosin solution has been used as an antimicrobial agent in antibiotic susceptibility minimal inhibitory concentration(MIC) of E. coli and S. aureus isolates. It has also been used as a component of Dulbecco′s modified Eagle′s (DMEM) medium for self-inactivating lentivirus production and skin fibroblast cultivation.

Biochem/physiol Actions

Tylosin inhibits bacterial protein synthesis by binding to the large subunit 50S. It is effective against Gram-positive bacteria and mycoplasma and is used in veterinary medicine. It has been used to study implant site abscess prevention in cattle and Mycoplasma gallisepticum and Mycoplasma meleagridis infections.

Packaging

20ML

Preparation Note

This product was formulated to contain 8 mg/ml tylosin in 0.9% sodium chloride.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable