SRP4739
PLGF-1 human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Synonym(s):
PGF, PIGF, PLGF 1, Placenta Growth Factor-1
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About This Item
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biological source
human
recombinant
expressed in E. coli
Assay
≥95% (HPLC)
≥95% (SDS-PAGE)
form
lyophilized
mol wt
~29.7 kDa
packaging
pkg of 25 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... PGF(5228)
General description
PLGF (placental growth factor), originally identified in human placenta, is a member of the VEGF (vascular endothelial growth factor) family. This protein is predominantly expressed in placenta, and also shows expression in heart, thyroid, lung and skeletal muscle. It is alternatively spliced to produce three isoforms in humans namely, PLGF1, PLGF2 and PLGF3.
Recombinant mouse PLGF is a disulfide-linked homodimer containing two 142 amino acid polypeptide chains.
Recombinant mouse PLGF is a disulfide-linked homodimer containing two 142 amino acid polypeptide chains.
Biochem/physiol Actions
PLGF (placental growth factor) is involved in angiogenesis, but does not play an essential role in angiogenesis during reproduction and development. However, inactivation of this gene in pathological conditions such as, ischemia, inflammation and cancer, results in impaired angiogenesis. Preclinical studies show that this protein might be a therapeutic target for treatment of angiogenesis and inflammation related disorders. In acute coronary syndrome (ACS) patients, increased levels of PLGF are linked with obstructive sleep apnea (OSA) and short-term adverse outcomes.
Physical form
Sterile filtered and lyophilized with no additives.
Reconstitution
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute the protein in sterile 20 mM acetic acid to a concentration of 0.1-1.0 ug/ul. The solution can then be diluted into other aqueous buffer.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Impact of Obstructive Sleep Apnea on the Levels of Placental Growth Factor (PlGF) and Their Value for Predicting Short-Term Adverse Outcomes in Patients with Acute Coronary Syndrome.
Barcelo A, et al.
PLoS ONE, 11(3) (2016)
Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders.
Autiero M, et al.
Journal of Thrombosis and Haemostasis, 1(7), 1356-1370 (2003)
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