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SML1785

Sigma-Aldrich

Landiolol hydrochloride

≥98% (HPLC)

Synonym(s):

4-[(2S)-2-Hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-benzenepropanoic acid [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ester hydrochloride, 4-[2-Hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-benzenepropanoic acid [S-(R*,R*)]-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl ester hydrochloride, ONO 1101, ONO-1101

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About This Item

Empirical Formula (Hill Notation):
C25H39N3O8 · HCl
CAS Number:
144481-98-1
Molecular Weight:
546.05
MDL number:
MFCD01937430
UNSPSC Code:
12352200
PubChem Substance ID:
329826064

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 25 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1(C)OC[C@@H](COC(CCC2=CC=C(OC[C@@H](O)CNCCNC(N3CCOCC3)=O)C=C2)=O)O1.[H]Cl

InChI

1S/C25H39N3O8.ClH/c1-25(2)35-18-22(36-25)17-34-23(30)8-5-19-3-6-21(7-4-19)33-16-20(29)15-26-9-10-27-24(31)28-11-13-32-14-12-28;/h3-4,6-7,20,22,26,29H,5,8-18H2,1-2H3,(H,27,31);1H/t20-,22+;/m0./s1

InChI key

DLPGJHSONYLBKP-IKGOIYPNSA-N

Biochem/physiol Actions

Landiolol is an ultra-short acting cardioselective β-adrenoceptor antagonist the exhibit β1-selectivity. New data shows that landiolol lacks pharmacochaperoning activity.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315 - H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Shahrooz Nasrollahi-Shirazi et al.
The Journal of pharmacology and experimental therapeutics, 359(1), 73-81 (2016-07-28)
Blockage of β1-adrenergic receptors is one of the most effective treatments in cardiovascular medicine. Esmolol was introduced some three decades ago as a short-acting β1-selective antagonist. Landiolol is a more recent addition. Here we compared the two compounds for their
Shigeki Kobayashi et al.
PloS one, 10(1), e0114314-e0114314 (2015-01-24)
The purpose of this study was to investigate whether adding a low-dose β1-blocker to milrinone improves cardiac function in failing cardiomyocytes and the underlying cardioprotective mechanism. The molecular mechanism underlying how the combination of low-dose β1-blocker and milrinone affects intracellular
Yoshiyasu Ogura et al.
Life sciences, 118(2), 347-356 (2014-05-23)
Endothelin (ET)-1 is the best known potent vasoconstrictor and has been implicated in pathogenesis of sepsis-associated acute kidney injury (AKI) in human or lipopolysaccharide (LPS)-induced AKI in animal models. We have previously shown that ET-1 is highly up-regulated in renal

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