SAE0154

E64 Ready Made solution

Non-freezing solution, 1 mg/mL

• UNSPSC Code: 12352204
• NACRES: NA.54

Properties

• Quality Level: 200
• form: ready-to-use solution
• shipped in: wet ice
• storage temp.: −20°C

Description

General description

E-64 is a cysteine protease inhibitor that effectively inhibits various cysteine proteases such as: cathepsin K, cathepsin L, cathepsin S known also as N-[N-(L-3-trans-carboxyoxiran-2-carbonyl)-L-leucyl]-agmatine, E-64 was isolated from the mold Aspergillus japonicus TPR-64.

Biochem/physiol Actions

E-64 is an highly selective, potent and irreversible cysteine protease inhibitor. The trans-epoxysuccinyl group of E-64 is its active moiety, and irreversibly binds to an active thiol group of many cysteine proteases, such as papain, actinidase, and cathepsins B, H and L, to form a thioether linkage.

Preparation Note

This E-64 Ready Made Solution is supplied as a proprietary 2.8 mM non-freezing solution formulation.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable