SAB4504388

Anti-phospho-eIF2 α (pSer⁵¹) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-EIF-2, Anti-EIF-2A, Anti-EIF-2alpha, Anti-EIF2, Anti-EIF2A
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 36 kDa
• species reactivity: human, mouse, rat
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:10000; western blot: 1:500-1:1000
• NCBI accession no.: P05198
• UniProt accession no.: P05198
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer51)
• Gene Information: human ... EIF2S1(1965)

Description

General description

EIF2S1 (eukaryotic translation initiation factor 2 subunit α) is a heterotrimeric protein and a regulatory subunit of eIF2 . eIF2 has three general subunits- α, βand γ . eIF2α is located on human chromosome 14q23 .

Immunogen

The antiserum was produced against synthesized peptide derived from human eIF2 alpha around the phosphorylation site of Ser51.

Immunogen Range: 21-70

Application

Anti-phospho-eIF2 α(pSer51) antibody has been used in western blotting and immunohistochemistry.

Biochem/physiol Actions

EIF2S1 (eukaryotic translation initiation factor 2 subunit α) acts as a modulator in apoptosis signaling pathway . During endoplasmic reticulum stress, eIF2α plays a major role in signaling pathways in the development of tumor .

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable