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SAB4300587

Sigma-Aldrich

Anti-JAK2 (Ab-570) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-JTK10 antibody produced in rabbit, Anti-Janus kinase 2 (a protein tyrosine kinase) antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.43

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~125 kDa

species reactivity

rat, human

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100

isotype

IgG

immunogen sequence

(G-D-Y-G-Q)

NCBI accession no.

NP_004963.1

UniProt accession no.

O60674

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... JAK2(3717)

Related Categories

General description

JAK2 (janus kinase 2) encodes a tyrosine kinase. It belongs to the the Jak family of protein. It is located on chromosome 9p24.

Immunogen

Peptide sequence around aa. 568-572 (G-D-Y-G-Q), according to the protein JAK2.

Biochem/physiol Actions

JAK2 (janus kinase 2) plays an important role in the activities of cytokines receptors. Overexpression of JAK2 results in neuroblastoma. JAK2 mutations promote primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Plays a role in leptin signaling and control of body weight.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2
Joos S, et al.
International Journal of Cancer. Journal International Du Cancer, 103(4), 489-495 (2003)
Jak2 is essential for signaling through a variety of cytokine receptors
Parganas E, et al.
Cell, 93(3), 385-395 (1998)
Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells.
Borriello L
Cancer Research, 77(18), 5142-5157 (2017)
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
Shin DS
Cancer Discovery, 7(2), 188-201 (2017)
Lin Miao et al.
Cancer immunology, immunotherapy : CII, 63(7), 699-711 (2014-04-11)
Gastric cancer remains the second leading cause of cancer-related deaths worldwide. Although Helicobacter pylori (H. pylori) is considered to be a critical risk factor, the molecular mechanisms underlying H. pylori-induced gastric carcinogenesis are still poorly defined. Recently, accumulating studies have
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