SAB4300255

Anti-phospho-NTRK2 (pTyr⁵¹⁵) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-GP145-TrkB antibody produced in rabbit, Anti-TRKB antibody produced in rabbit, Anti-neurotrophic tyrosine kinase, receptor, type 2 antibody produced in rabbit
• MDL number: MFCD01092509
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~140 kDa
• species reactivity: mouse, rat, human
• concentration: 1 mg/mL
• technique(s): indirect immunofluorescence: 1:100-1:200
• isotype: IgG
• immunogen sequence: (P-Q-Y-PF-G)
• NCBI accession no.: NP_001007098.1
• UniProt accession no.: Q16620
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr515)
• Gene Information: human ... NTRK2(4915)

Description

General description

NTRK2 (neurotrophic tyrosine kinase receptor type 2) is also known as TRKB (tropomyosin receptor kinase B). It belongs to the Trk family of neurotrophin receptors. It is located on chromosome 9q21.32.

Immunogen

Peptide sequence around phosphorylation site of tyrosine 515 (P-Q-Y(p)-F-G), according to the protein NTRK2.

Application

Anti-phospho-NTRK2 (pTyr515) antibody has been used in western blotting.

Biochem/physiol Actions

In NB (neuroblastoma), NTRK2 (neurotrophic tyrosine kinase receptor type 2) controls the favorable and unfavorable clinical actions. It also controls the roles of glutamate receptor and synaptic plasticity in the amygdala .

Features and Benefits

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Target description

Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable