S7446
Superoxide Dismutase from bovine erythrocytes
BioUltra, lyophilized powder, ≥4,500 units/mg protein, ≥97% (SDS-PAGE)
Synonym(s):
SOD, Superoxide: superoxide oxidoreductase
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About This Item
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product line
BioUltra
Quality Level
Assay
≥97% (SDS-PAGE)
form
lyophilized powder
specific activity
≥4,500 units/mg protein
mol wt
32.5 kDa
composition
Protein, ≥95% biuret
relevant disease(s)
arthritis
storage temp.
−20°C
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General description
Superoxide dismutases are a group of low molecular weight metalloproteins present in all aerobic cells of plants, animals and micro-organisms. They provide protection against damaging reactions with the superoxide radical anion (O2-) by catalyzing its disproportionation into oxygen and hydrogen peroxide.
Application
Superoxide Dismutase from bovine erythrocytes has been used in a study to assess activity parameters in adjuvant-induced arthritis. Superoxide Dismutase from bovine erythrocytes has also been used in a study to simplify the process of purifying superoxide dismutases using charge-controlled hydrophobic chromatography on 10-carboxydecyl Sepharose.
Biochem/physiol Actions
Superoxide Dismutase from bovine erythrocytes catalyzes the dismutation of superoxide radicals to hydrogen peroxide and molecular oxygen. It serves as an antioxidant and plays a critical role in the defense of cells against the toxic effects of oxygen radicals. Competes with nitric oxide (NO) for superoxide anion (which reacts with NO to form peroxynitrite), thereby SOD promotes the activity of NO. SOD has also been shown to suppress apoptosis in cultured rat ovarian follicles, neural cell lines, and transgenic mice.
Unit Definition
One unit will inhibit reduction of cytochrome c by 50% in a coupled system with xanthine oxidase at pH 7.8 at 25 °C in a 3.0 mL reaction volume. Xanthine oxidase concentration should produce an initial ΔA550 of 0.025 ± 0.005 per min.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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A García-González et al.
Archives of medical research, 30(2), 132-137 (1999-06-18)
The purpose of this work was to evaluate the effect of superoxide dismutase (SOD) on primary swelling, lipoperoxidation, body thymus, and spleen weight in the adjuvant-induced arthritis (AIA) model in rats. Orally and intraperitoneally administered SOD (100 U/kg) from bovine
Purification of pro- and eukaryotic superoxide dismutases by charge-controlled hydrophobic chromatography
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Journal of Chromatography A, 590, 247-253 (1992)
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Protocols
Enzymatic Assay of Superoxide Dismutase
Separation of Superoxide dismutase
Chromatograms
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