RAB1515
Human IL-12 R beta 2 ELISA
for serum, plasma and cell culture supernatants
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About This Item
UNSPSC Code:
41116158
NACRES:
NA.32
Recommended Products
species reactivity
human
technique(s)
ELISA: suitable
input
sample type plasma
sample type cell culture supernatant(s)
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IL12RB2(3595)
General description
The IL12RB2 (interleukin 12 receptor subunit β 2) gene is mapped to human chromosome 1p31.3 and codes for the β2 chain (130 kDa) of IL-12 receptor.
This ELISA antibody pair detects human IL-12 R beta 2. Other species not yet determined.
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
Biochem/physiol Actions
Il12rb2 (interleukin 12 receptor subunit β 2) stimulates the release of interferon γ and Th1 (T helper cell 1) cell differentiation, as a part of autoimmune response. Il12rb2′s major function is associated with cell mediated immune system. In mice model, deletion of L12RB2 gene is associated with autoimmune and malignant disorders.
Other Notes
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Identification of susceptibility SNPs in IL10 and IL23R-IL12RB2 for Behcet's disease in Han Chinese.
Yu H, et al.
The Journal of Allergy and Clinical Immunology, 139(2), 621-627 (2017)
IL12RB2 Polymorphisms correlate with risk of lung adenocarcinoma.
Prigione I, et al.
Immunobiol., 221(2), 291-299 (2016)
Association study of rs924080 and rs11209032 polymorphisms of IL23R-IL12RB2 in a Northern Chinese Han population with Behcet?s disease.
Qin X, et al.
Human immunology, 77(12), 1284-1290 (2016)
An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation.
Roberts A R, et al.
Annals of the Rheumatic Diseases (2016)
Nahoko Kato-Kogoe et al.
Immunogenetics, 68(1), 55-65 (2015-11-11)
Interleukin 12 receptor β chain (IL12RB2) is a crucial regulatory factor involved in cell-mediated immune responses, and genetic variants of the gene encoding IL12RB2 are associated with susceptibility to various immune-related diseases. We previously demonstrated that haplotypes with single nucleotide
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