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P9357

Sigma-Aldrich

Anti-Potassium Channel Kv1.5 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-ATFB7, Anti-HCK1, Anti-HK2, Anti-HPCN1, Anti-KV1.5, Anti-PCN1

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About This Item

MDL number:
MFCD02097213
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse, rat

technique(s)

western blot (chemiluminescent): 1:200-1:400

UniProt accession no.

Q61762

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Kcna5(16493)
rat ... Kcna5(25470)

General description

Pivotal role of potassium channel is maintaining cell volume, membrane potential and neuronal excitability. Two families of potassium channel exists- one with inwardly rectifying potassium channel and the other with voltage sensing (KV) big conductance, calcium activated (BKCA ) small conductance and calcium activated (SK) potassium channel. KV1.5 channel is O2 sensitive, so hypoxia inhibits the expression of KV1.5 channel through 15-HETE pathway. Anti-Potassium Channel Kv1.5 antibody reacts specifically with full length Kv1.5 protein of rat and mouse.

Immunogen

GST fusion protein from the C-terminal of mouse potassium channel Kv1.5 corresponding to amino acids 513-602.

Application

Anti-Potassium Channel Kv1.5 antibody can be used in immunocytochemistry, immunoblotting and immunofluorescence.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Gloria Juliana Rey-Parra et al.
American journal of respiratory and critical care medicine, 178(4), 399-406 (2008-05-31)
Neonatal chronic lung disease (CLD), caused by prolonged mechanical ventilation (MV) with O(2)-rich gas, is the most common cause of long-term hospitalization and recurrent respiratory illness in extremely premature infants. Recurrent episodes of hypoxemia and associated ventilator adjustments often lead
Xiaojie Chu et al.
Prostaglandins & other lipid mediators, 88(1-2), 42-50 (2008-11-06)
Hypoxia initiated pulmonary vasoconstriction is due to the inhibition of voltage-gated K(+) (K(V)) channels. But the mechanism is unclear. We have evidence that hypoxia activates 15-lipoxygenase (15-LOX) in distal pulmonary arteries and increases the formation of 15-hydroxyeicosatetraenoate (15-HETE). 15-HETE-induced pulmonary
B Attali et al.
The Journal of biological chemistry, 268(32), 24283-24289 (1993-11-15)
The mouse Kv1-5 K+ channel cDNA has been cloned from heart. This channel was highly expressed in heart and, to a lesser extent, in other tissues, including brain and thymus. Two alternatively spliced isoforms were found. The longer form encoded
R Swanson et al.
Neuron, 4(6), 929-939 (1990-06-01)
Rat brain cDNA and genomic clones encoding three K+ channels, Kv1, Kv2, and Kv3, have been isolated by screening with Shaker probes and encode proteins of 602, 530, and 525 amino acids. Each of the deduced protein sequences contains six

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