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P9233

Sigma-Aldrich

Piribedil maleate salt

Synonym(s):

2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine maleate salt

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About This Item

Empirical Formula (Hill Notation):
C20H22N4O6
CAS Number:
937719-94-3
Molecular Weight:
414.41
MDL number:
MFCD02684412
UNSPSC Code:
12352200
PubChem Substance ID:
24278661
NACRES:
NA.77

form

powder

solubility

DMSO: >10 mg/mL
H2O: >10 mg/mL

originator

Servier

storage temp.

2-8°C

SMILES string

[H]\C(=C(/[H])C(O)=O)C(O)=O.C1Oc2ccc(CN3CCN(CC3)c4ncccn4)cc2O1

InChI

1S/C16H18N4O2.C4H4O4/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14;5-3(6)1-2-4(7)8/h1-5,10H,6-9,11-12H2;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

DKGOFBARSQSLOW-BTJKTKAUSA-N

Gene Information

human ... DRD3(1814)

Biochem/physiol Actions

A direct dopamine agonist; may be selective for the D3 subtype; no significant affinity for D1 receptors.

Features and Benefits

This compound was developed by Servier. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A Cagnotto et al.
European journal of pharmacology, 313(1-2), 63-67 (1996-10-10)
Receptor binding autoradiography, using the selective ligand [3H]7-OH-(R)DPAT (R(+)-2-dipropylamino-7-hydroxy 1,2,3,4-tetrahydronaphthalene), showed that piribedil is a potent inhibitor at dopamine D3 receptors in limbic regions (island of Calleja), with affinity (IC50) between 30 and 60 nM. The in vitro IC50 of

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