N3279
Monoclonal Anti-Nerve Growth Factor-β antibody produced in mouse
clone 25623, purified immunoglobulin, lyophilized powder
Synonym(s):
Anti-NGF-β
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About This Item
Recommended Products
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
25623, monoclonal
form
lyophilized powder
species reactivity
human, rat, mouse
technique(s)
capture ELISA: 2-8 μg/mL (detection antibody at 0.1-0.4 μg/ml)
neutralization: 0.1-0.4 μg/mL
impurities
endotoxin, tested
isotype
IgG1
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... NGF(4803)
mouse ... Ngf(18049)
Immunogen
recombinant human NGF-β.
Biochem/physiol Actions
Nerve Growth factor (NGF) is a growth factor that is essential for the development and maintenance of the nervous system. NGF is composed of three non-covalently linked α, β and γ subunits. The β subunit is responsible for the biological functions of NGF. Nerve growth factor (NGF) binds to either to NGF receptor (NGFR) or the Trk receptor and can elicit biological responses through each of the receptors independently. NGF is important in the survival and differentiation of neurons and neural crest-derived cells during embryonic and early postnatal development and maintenance of peripheral neurons. NGF is also implicated in inflammation and allergic reactions.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Preparation Note
Purified using Protein G.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Josemberg S Baptista et al.
PloS one, 15(1), e0228155-e0228155 (2020-01-28)
Intervertebral disc (IVD) degeneration is a remodeling process mediated by several growth factors and cytokines. This process has been extensively studied in vitro and with pathologic specimens obtained during surgery for scoliosis or back pain. However, the occurrence and temporal
E Formaggio et al.
Neuroscience, 166(2), 580-589 (2010-01-09)
In this study, we investigated whether the potential positive effects of nicotine in Alzheimer's disease (AD) may involve neurotrophic factors, such as nerve growth factor (NGF), closely associated with basal forebrain (BF) cholinergic function and survival. To this aim, we
Elena Formaggio et al.
Neuroscience research, 62(1), 32-42 (2008-07-09)
In this work, we define a GFP-tagged version of the p75 neurotrophin receptor (p75GFP) as a useful molecular tool for studying its distribution and cellular dynamics. Expression and subcellular localization of p75GFP have been characterized in non-neuronal (HEK 293) and
R Judith et al.
Life sciences, 87(1-2), 1-8 (2010-05-18)
The objective of this study was to develop an acellular provisional matrix to mimic the extracellular matrix (ECM) of a wound site, and to evaluate its potential for in vivo dermal regeneration. This study evaluates the potential of a monomeric
Seong Hoon Seo et al.
The Journal of investigative dermatology, 140(11), 2199-2209 (2020-04-06)
Itch in atopic dermatitis (AD) is aggravated under warm conditions. Transient receptor potential vanilloid (TRPV) 3, a member of the thermosensitive transient receptor potential channels, is activated by innocuous heat and is abundantly expressed in keratinocytes. The potential role of
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