D4268

N^G,N^G-Dimethylarginine dihydrochloride

• Synonym(s): asym-Dimethylarginine, ADMA
• Empirical Formula (Hill Notation): C₈H₁₈N₄O₂ · 2HCl
• CAS Number: 220805-22-1
• Molecular Weight: 275.18
• MDL number: MFCD00270857
• UNSPSC Code: 12352209
• PubChem Substance ID: 24278027
• NACRES: NA.77

Properties

• Assay: ≥98% (TLC)
• Quality Level: 200
• form: powder
• solubility: water: 50 mg/mL, clear, colorless
• storage temp.: room temp
• SMILES string: Cl[H].Cl[H].CN(C)C(=N)NCCC[C@H](N)C(O)=O
• InChI: 1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1
• InChI key: SYLNVYJOPZWPJI-ILKKLZGPSA-N
• Gene Information: human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846)

Description

General description

N^G,N^G-Dimethylarginine dihydrochloride is a methylated arginine derivative, which is produced by the liver. It is linked to liver cirrhosis, alcoholic hepatitis and acute liver failure (ALF).

Application

N^G,N^G- Dimethylarginine dihydrochloride has been used:

• to study its effects on cardiovascular activities in rostral ventrolateral medulla (RVLM) in rats
• as a standard for measuring L-arginine and dimethylarginines
• to study its effects on hepatic deterioration

Biochem/physiol Actions

Reversible inhibitor of nitric oxide synthetase in vivo and in vitro.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves