C0567

(−)-Catechin

≥97% (HPLC), from green tea

• Synonym(s): (−)-trans-3,3′,4′,5,7-Pentahydroxyflavane, (2S,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol
• Empirical Formula (Hill Notation): C₁₅H₁₄O₆
• CAS Number: 18829-70-4
• Molecular Weight: 290.27
• EC Number: 242-611-7
• MDL number: MFCD00135997
• UNSPSC Code: 12352200
• PubChem Substance ID: 24892260
• NACRES: NA.77

Properties

• biological source: green tea
• Quality Level: 200
• Assay: ≥97% (HPLC)
• form: powder
• storage temp.: 2-8°C
• SMILES string: O[C@@H]1Cc2c(O)cc(O)cc2O[C@H]1c3ccc(O)c(O)c3
• InChI: 1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15+/m1/s1
• InChI key: PFTAWBLQPZVEMU-HIFRSBDPSA-N
• Gene Information: human ... BACE1(23621)

Description

General description

Catechins are major flavonoids present in green tea accounting to 90%. (−)-catechin is comparatively less bioavailable than the (+)-catechin for intestinal absorption.

Application

(-)-Catechin has been used:

• to test its binding affinity towards estrogen receptor
• as a reference standard in high-performance liquid chromatography for quantification of polyphenols from plant extracts (HPLC)
• as a reference standard in kinetic studies to quantify antioxidants from Iranian green tea leaves

Biochem/physiol Actions

Catechins have wide biological functionality. They induce antiviral and anticancer activities. Catechins also play a key role in regulating carbohydrate and lipid metabolism. It prevents fat accumulation.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315 - H319 - H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves