A7655

Atenolol

≥98% (TLC), powder, β₁-adrenoceptor antagonist

• Synonym(s): (±)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide, 4-[2′-Hydroxy-3′-(isopropylamino)propoxy]phenylacetamide
• Empirical Formula (Hill Notation): C₁₄H₂₂N₂O₃
• CAS Number: 29122-68-7
• Molecular Weight: 266.34
• EC Number: 249-451-7
• MDL number: MFCD00057645
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277748
• NACRES: NA.77

Properties

• product name: Atenolol, ≥98% (TLC), powder
• Assay: ≥98% (TLC)
• form: powder
• color: white to off-white
• solubility: H₂O: 0.3 mg/mL; DMSO: 18 mg/mL; ethanol: 3.4 mg/mL
• originator: AstraZeneca
• SMILES string: CC(C)NCC(O)COc1ccc(CC(N)=O)cc1
• InChI: 1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)
• InChI key: METKIMKYRPQLGS-UHFFFAOYSA-N
• Gene Information: human ... ADRB1(153) ; rat ... Adrb1(24925)

Description

Application

Atenolol is a β-adrenergic blocker and used in the management of hypertension. Atenolol has antianginal and antiarrhythmic properties.

Biochem/physiol Actions

Selective β₁-adrenoceptor antagonist; antihypertensive; antianginal; antiarrhythmic.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Shelf-life of the solid is at least three years.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves