P8721

Penicillin G potassium salt

• Synonym(s): Benzylpenicillin potassium salt
• Empirical Formula (Hill Notation): C₁₆H₁₇KN₂O₄S
• CAS Number: 113-98-4
• Molecular Weight: 372.48
• Beilstein: 3832841
• EC Number: 204-038-0
• MDL number: MFCD00036193
• UNSPSC Code: 51283405
• eCl@ss: 34010400
• PubChem Substance ID: 24898970
• NACRES: NA.21

Properties

• form: crystalline powder
• Quality Level: 200
• potency: 1440-1680 units per mg
• solubility: H₂O: 100 mg/mL
• antibiotic activity spectrum: Gram-positive bacteria
• application(s): pharmaceutical (small molecule)
• Mode of action: cell wall synthesis | interferes
• SMILES string: [K+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc3ccccc3)C([O-])=O
• InChI: 1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
• InChI key: IYNDLOXRXUOGIU-LQDWTQKMSA-M

Description

General description

Chemical structure: ß-lactam

Application

Penicillin G is a narrow spectrum antibiotic derived from Streptococcus pneumoniae. It is the drug of choice for groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridians group streptococci, and non-penicillinase producing staphylococcus. The potassium salt has been used to study murosomes of staphylococci and the penicillin-induced lysis of Streptococcus mutans.

Biochem/physiol Actions

Mode of Action: Penicillin G acts by inhibiting cell wall synthesis through binding to penicillin binding proteins (PBPs), inhibiting peptidoglycan chain cross-linking.

Antimicrobial spectrum: This product is active against gram-positive and gram-negative bacteria.

Packaging

10mu,25mu,100mu

Caution

Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for more lengthy periods. Solutions are stable at 37°C for 3 days. The sodium salt is soluble in H₂O at 100 mg/mL.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H317
• Precautionary Statements: P280 - P302 + P352
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves