32991
Lanoconazole
VETRANAL®, analytical standard
Synonym(s):
2-[4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene]-2-imidazol-1-yl-acetonitrile
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About This Item
Empirical Formula (Hill Notation):
C14H10ClN3S2
CAS Number:
Molecular Weight:
319.83
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
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grade
analytical standard
Quality Level
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
clinical testing
format
neat
storage temp.
2-8°C
SMILES string
Clc1ccccc1C2CS\C(S2)=C(\C#N)n3ccnc3
InChI
1S/C14H10ClN3S2/c15-11-4-2-1-3-10(11)13-8-19-14(20-13)12(7-16)18-6-5-17-9-18/h1-6,9,13H,8H2/b14-12+
InChI key
ZRTQSJFIDWNVJW-WYMLVPIESA-N
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General description
Lanoconazole is a member of the imidazole family and an antifungal agent, which finds applications as an antidermatophytic drug.
Application
Lanoconazole may be used as a reference standard in the determination of lanoconazole in pharmaceutical formulations using high-performance liquid chromatography coupled with an ultraviolet detector (HPLC-UV).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
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Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Y Niwano et al.
Arzneimittel-Forschung, 47(9), 1056-1060 (1997-10-29)
To answer the question why topically applied lanoconazole (CAS 101530-10-3, NND-318) is so highly effective in the treatment of dermatomycoses in both animal models and human patients, the antifungal activity of lanoconazole in infected sites was investigated. 1. Distribution of
Shigehiro Hagiwara et al.
Mycopathologia, 184(1), 13-21 (2018-10-07)
Aspergillus species are the most common pathogenic fungi involved in otomycosis, an infection of the outer ear canal. In this study, we examined the incidence of Aspergillus infections and the antifungal susceptibilities of 30 Aspergillus species isolates from patients with
M A Ghannoum et al.
Medical mycology, 48(3), 491-497 (2010-04-08)
The in vivo efficacy of terbinafine was compared to lanoconazole and luliconazole in the topical treatment of dermatophytosis caused by Trichophyton mentagrophytes using a guinea pig model. Topical antifungal treatment commenced three days post-infection, and each agent was applied once
H Tanuma et al.
Mycoses, 44(5), 181-190 (2001-08-07)
Hyperkeratotic type tinea pedis is a refractory type of superficial dermatomycosis. Treatment for hyperkeratotic type tinea pedis is mainly with oral antimycotics, such as griseofulvin, and healing is generally considered to be difficult with only topical antimycotics. In this randomized
Yukio Oku et al.
Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology, 43(3), 181-187 (2002-07-30)
The fungicidal activities of thiocarbamate antifungal agent liranaftate were studied by determining the MIC and the MCC against Trichophyton rubrum with the Milliflex -100 Test System and by determining the time-kill curve in comparison to that of six reference agents.
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