07386

Coenzyme Q₁₀

analytical standard

• Synonym(s): Q-10, Ubiquinone 50, Ubiquinone-10
• Empirical Formula (Hill Notation): C₅₉H₉₀O₄
• CAS Number: 303-98-0
• Molecular Weight: 863.34
• Beilstein: 1900141
• EC Number: 206-147-9
• MDL number: MFCD00042919
• UNSPSC Code: 85151701
• PubChem Substance ID: 329748422
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 100
• Assay: ≥97.5% (HPLC)
• form: powder
• shelf life: limited shelf life, expiry date on the label
• impurities: ≤1.0% water
• color: faint yellow to dark orange
• mp: 49 °C
• application(s): cleaning products; cosmetics; food and beverages; personal care
• format: neat
• storage temp.: −20°C
• SMILES string: O=C(C(OC)=C1OC)C(C/C=C(C)/CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)\C)\C)\C)\C)\C)=C(C)C1=O
• InChI: 1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
• InChI key: ACTIUHUUMQJHFO-UPTCCGCDSA-N

Description

General description

Coenzyme Q₁₀ is the central electron carrier in mitochondrial respiratory chain, originating from food intake as well as from endogenous synthesis. It commonly acts in its reduced form to prevent lipid peroxidation in biological membranes and in serum low-density lipoproteins (LDL). It also tends to protect the mitochondrial membrane proteins and DNA against oxidative damage along with lipid peroxidation.

Application

• Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-kB/NLRP3 inflammasome axis and attenuating oxidative stress in mice: Research demonstrates Coenzyme Q10′s effectiveness in reducing cardiac damage through antioxidant mechanisms and inflammation modulation, offering insights for potential human therapeutic applications (Antar et al., 2024).


• Adverse hematological profiles associated with chlorpromazine antipsychotic treatment in male rats: Preventive and reversal mechanisms of taurine and coenzyme-Q10: This study explores how Coenzyme Q10, along with taurine, can mitigate the negative hematological effects of chlorpromazine, suggesting its use in managing side effects in psychiatric treatments (Obukohwo et al., 2024).


• Nutritional Strategies for Muscle Atrophy: Current Evidence and Underlying Mechanisms: Discusses the role of Coenzyme Q10 in muscle health, particularly in preventing atrophy through mitochondrial support and enhancing cellular energy metabolism, pertinent for sports medicine and aging (Shen et al., 2024).


• Identification of a family of species-selective complex I inhibitors as potential anthelmintics: Although indirectly related, this study hints at the role of mitochondrial function, which could be linked to Coenzyme Q10′s effects in similar pathways, suggesting a novel application area in parasitology and infectious diseases (Davie et al., 2024).

Caution

light sensitive

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Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable