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Key Documents

MABC282

Sigma-Aldrich

Anti-BAG3 Antibody, clone AC-1

clone AC-1, from mouse

Synonym(s):

BAG family molecular chaperone regulator 3, BAG-3, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

AC-1, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable

isotype

IgG1κ

NCBI accession no.

NP_004272

UniProt accession no.

O95817

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... BAG3(9531)

General description

Bcl2-associated athanogene 3 (BAG3), also known as CAIR-1 or Bis, belongs to a family of six evolutionarily conserved co-chaperone proteins that contain a characteristic C-terminal BAG domain. In most cell types, BAG3 is localized to the cytoplasm, where it regulates the heat shock protein 70 chaperone. BAG3 is activated in response to stressful stimuli, and plays a critical role in modulating multiple cellular processes, including apoptosis, autophagy, embryonic development, and actin rearrangement. Abnormal expression of BAG3 results cardiomyopathy dilated type 1HH.

Application

Detect BAG3 using this Anti-BAG3 Antibody, clone AC-1 validated for use in Immunoprecipitation, IHC(P).

Quality

Evaluated by Immunoprecipitation in HeLa cell lysate.

Immunoprecipitation Analysis: 10 µg of this antibody immunoprecipitated BAG3 from HeLa cell lysate.

Target description

~62 kDa observed

Physical form

Format: Purified

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Alessandra Rosati et al.
The American journal of pathology, 181(5), 1524-1529 (2012-09-05)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly cancers, being the fourth leading cause of cancer-related deaths. Long-term survival reaching 15% is achieved in less than 5% of patients who undergo surgery, and median survival is only 6
BAG3 controls angiogenesis through regulation of ERK phosphorylation.
Falco, A, et al.
Oncogene (2012)

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