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Key Documents

MAB3301

Sigma-Aldrich

Anti-TIMP-1 Antibody, clone 147-6D11

clone 147-6D11, Chemicon®, from mouse

Synonym(s):

Tissue Inhibitor of Metalloproteinase-1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

147-6D11, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NM_003254.2

UniProt accession no.

P01033

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... TIMP1(7076)

Specificity

The antibody specifically reacts with human TIMP-1. This is a purified mouse monoclonal antibody to recombinant human tissue inhibitor of metalloproteinases-1 (recombinant TIMP-1).

SPECIES REACTIVITY:

Does not cross-react with mouse and rat TIMP-1.

Immunogen

Mouse Mac-1

Application

Immunoblotting: Suggested Dilution 1μg/mL

Immunohistochemistry on paraffin-embedded tissue sections using PLP fixation; not tested on traditional formalin fixed tissues. Antigen retrieval is HIER methods

ElA
This Anti-TIMP-1 Antibody, clone 147-6D11 is validated for use in ELISA, WB, IH(P) for the detection of TIMP-1.

Linkage

Replaces: MAB1338

Physical form

Format: Purified

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Marcia Riboldi et al.
Reproduction (Cambridge, England), 160(5), 673-684 (2020-10-17)
During embryo implantation, endometrial angiogenesis is regulated by signals originating from the endometrium itself and the developing embryo. It has been suggested that hCG may play a pro-angiogenic role; therefore, we sought to understand its regulatory role in blood vessel
Expression of TIMP-1 in Pichia pastoris. Selection of an anti-TIMP-1 specific single-chain Fv antibody from a large non-immune library.
Gordana Wozniak, Eva Obermayr, Matjaz Jeras, Mio Knezevic, Florian Ruker
Clinica Chimica Acta; International Journal of Clinical Chemistry null
A Tapia-Pizarro et al.
Human reproduction (Oxford, England), 28(8), 2215-2227 (2013-05-23)
Are secreted extracellular matrix (ECM) remodelling elements, relevant to embryo implantation and placentation, modified by hCG in endometrial stromal cells (ESCs)? hCG decreases tissue inhibitor of metalloproteinase 1 (TIMP-1) secretion in ESCs, thereby facilitating extravillous trophoblast invasion in vitro. Successful
Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases.
F A Attiga, P M Fernandez, A T Weeraratna, M J Manyak, S R Patierno
Cancer Research null
Elevated levels of circulating plasma matrix metalloproteinase 9 in non-small cell lung cancer patients.
Iizasa, T, et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 5, 149-153 (1999)

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