475874-M

MK571, Sodium Salt

A selective, competitive antagonist of leukotriene D4 (LTD4) (K_i = 2.1 nM for inhibition of [³H]LTD4 binding to human lung membranes).

• Synonym(s): MK571, Sodium Salt, L 660711, Sodium Salt, (E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic Acid, Sodium Salt
• Empirical Formula (Hill Notation): C₂₆H₂₆ClN₂O₃S₂ · Na
• CAS Number: 115104-28-4
• Molecular Weight: 537.07
• UNSPSC Code: 12352211

Properties

• Quality Level: 100
• Assay: ≥90% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated
• color: off-white
• solubility: DMSO: 10 mg/mL; water: 200 mg/mL
• storage temp.: −20°C
• InChI: 1S/C26H27ClN2O3S2/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32)/b10-6+
• InChI key: AXUZQJFHDNNPFG-UXBLZVDNSA-N

Description

General description

A selective, competitive antagonist of leukotriene D₄ (LTD₄) (K_i = 2.1 nM for inhibition of [³H]LTD₄ binding to human lung membranes). Also inhibits multidrug resistance-associated protein 1 (MRP1).

A selective, competitive antagonist of leukotriene D₄ (LTD₄) receptor (K_i = 2.1 nM for inhibition of [³H]LTD₄ binding to human lung membranes). Also reported to inhibit multidrug resistance-associated protein 1 (MRP1).

Biochem/physiol Actions

Primary Target
Antagonist of leukotriene D4 (LTD4)

Target K_i: 2.1 nM for inhibition of [3H]LTD4 binding to human lung membranes

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions in are stable for up to 1 week at -20°C; DMSO stock solutions are stable for up to 6 months at -20°C. Acidic pH and heavy metals will accelerate decomposition.

Other Notes

Olson, D.P., et al. 2001. Cytometry46, 105.
Van der Kolk, D.M., et al. 1998. Clin. Cancer Res.4, 1727.
Jones, T.R., et al. 1989. Can. J. Physiol. Pharmacol.67, 17.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable