218753

Caspase-5 Inhibitor I

Z-WEHD-FMK is a cell-permeable, potent, irreversible caspase-5 inhibitor, that also inhibits the activity of Caspase 1, 4, and 8.

• Synonym(s): Caspase-5 Inhibitor I, Z-WE(OMe)HD(OMe)-FMK
• Empirical Formula (Hill Notation): C₃₇H₄₂FN₇O₁₀
• Molecular Weight: 763.77
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated
• color: white
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A potent, cell-permeable and irreversible inhibitor of caspase-5 (ICE_rel-III, TY), as well as caspase-1 and caspase-4.

A potent, cell-permeable, and irreversible inhibitor of caspase-5. Strongly inhibits caspase-1. Also inhibits caspase-4 and caspase-8.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-1, caspase-4, caspase-5, caspase-8

Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Trp-Glu(OMe)-His-Asp(OMe)-CH₂F*

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 4 months at 4°C.

Analysis Note

single spot by TLC

Other Notes

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Rano, T., et al. 1997. Chem. Biol. 4, 149.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable