1.37148

Triethanolamine

EMPROVE^® EXPERT, Ph. Eur., JPE, NF

• Synonym(s): 2,2′,2′′-Nitrilotriethanol, Tris(2-hydroxyethyl)amine
• Linear Formula: (HOCH₂CH₂)₃N
• CAS Number: 102-71-6
• Molecular Weight: 149.19
• Beilstein: 1699263
• MDL number: MFCD00002855
• UNSPSC Code: 12352104

Properties

• Agency: JPE; NF; Ph. Eur.
• Quality Level: 500
• vapor density: 5.14 (vs air)
• vapor pressure: 0.01 mmHg ( 20 °C)
• product line: EMPROVE^® EXPERT
• form: liquid
• autoignition temp.: 600 °F
• expl. lim.: 8.5 %
• technique(s): API processing | cocrystal formation: suitable
• refractive index: n20/D 1.485 (lit.)
• useful pH range: 7.3-8.3
• pKa (25 °C): 7.8
• bp: 190-193 °C/5 mmHg (lit.)
• mp: 17.9-21 °C (lit.)
• density: 1.124 g/mL at 25 °C (lit.)
• application(s): liquid formulation; pharmaceutical; semi-solid formulation
• storage temp.: 2-25°C
• SMILES string: OCCN(CCO)CCO
• InChI: 1S/C6H15NO3/c8-4-1-7(2-5-9)3-6-10/h8-10H,1-6H2
• InChI key: GSEJCLTVZPLZKY-UHFFFAOYSA-N

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Triethanolamine (Trolamine) is a tertiary amine that acts as a basic buffer component, typically used as a final formulation buffer for small molecules pharmaceuticals. It may also be used as a process buffer in cell lysis and biomolecule downstream chromatography.
As a multi-compendial product, Triethanolamine (Trolamine) Emprove^® Expert meets the N-nitrosodiethanolamine limits required by Ph Eur. Also, low microbial and endotoxin limits facilitate the use of this product in high-risk applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): 354.2 °F - closed cup
• Flash Point(C): 179 °C - closed cup