1.09888

Buffer concentrate

(borate/hydrochloric acid), traceable to SRM of NIST and PTB for 500 ml buffer solution, pH 8.00 ± 0.02 (20°C) Titrisol^®

• UNSPSC Code: 12161705

Properties

• grade: analytical standard
• Quality Level: 100
• Agency: according to DIN 19266
• product line: Titrisol^®
• pH: 8.00 (20 °C in H₂O)
• density: 1.00 g/cm³ at 20 °C
• application(s): environmental; food and beverages; general analytical; industrial qc; pharmaceutical
• format: mixture
• storage temp.: 15-25°C

Description

General description

The Titrisol^® reference buffer concentrate [borate/hydrochloric acid; pH=8.00±0.02 (20 °C)] is analyzed in the ISO/IEC 17025 accredited calibration laboratory with a combined glass electrode and 5-point calibration according to DIN 19268 against a certified primary standard reference material following DIN 19266.

The Titrisol^® concentrated buffer material combines ease of use and maximum precision for the routine calibration and monitoring of pH instruments. To prepare the ready-to-use pH buffer solution, simply dilute the Titrisol^® buffer concentrate.

Application

• Optimizing oral bioavailability in pharmaceuticals: Buffer concentrate is integral to the formulation of proniosomal drug delivery systems, as seen in the development of Irbesartan formulations where it enhances solubility and stability, facilitating improved bioavailability and therapeutic efficacy (Mujtaba et al., 2024).


• Environmental remediation: In environmental science, buffer concentrate is used to adjust the pH of solutions, ensuring optimal conditions for the mediation of electron transfers in contaminant remediation processes, particularly in treatments involving heavy metals like chromium (Li and Zhang, 2024).


• Biomedical research: Buffer concentrates are crucial for maintaining pH stability in biomedical experiments, such as studies on hemoglobin mass in response to apnea, which require precise control over biochemical conditions (Keeler et al., 2024).


• Chemical analysis: In analytical chemistry, buffer concentrates are used to stabilize the environment during the voltammetric determination of dyes, ensuring accuracy and repeatability in the detection of chemical substances (Moulya et al., 2024).

Features and Benefits

• Traceable to primary standard reference materials from NIST and PTB
• Analytical standard Grade
• Uncertainty data and traceability are documented in a comprehensive and batch-specific Certificate of Analysis.

Analysis Note

pH-value (20 °C): 8.00 ± 0.02
Measured after dilution to 500 ml with a combination glass electrode after multiple point calibration (according to DIN 19268) with reference materials for the preparation of standard buffer solutions according to DIN 19266.

Legal Information

Titrisol is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H360FD
• Precautionary Statements: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Storage Class Code: 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable