850520P

n-dodecyl-β-D-maltoside (DDM)

Avanti Polar Lipids

• Synonym(s): DDM; lauryl maltoside; dodecyl 4-O-α-D-glucopyranosyl-β-D-glucopyranoside
• Empirical Formula (Hill Notation): C₂₄H₄₆O₁₁
• CAS Number: 69227-93-6
• Molecular Weight: 510.62
• UNSPSC Code: 12161902
• NACRES: NA.25

Properties

• description: n-dodecyl-β-D-maltopyranoside
• Assay: >99% (contains <2% alpha isomer, TLC)
• form: powder
• mol wt: 510.62 g/mol
• packaging: pkg of 1 × 1 g (850520P-1g); pkg of 1 × 25 g (850520P-25g); pkg of 1 × 5 g (850520P-5g)
• manufacturer/tradename: Avanti Polar Lipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: OC[C@H]1O[C@@H](OCCCCCCCCCCCC)[C@H](O)[C@@H](O)[C@@H]1O[C@@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2
• InChI: 1S/C24H46O11/c1-2-3-4-5-6-7-8-9-10-11-12-32-23-21(31)19(29)22(16(14-26)34-23)35-24-20(30)18(28)17(27)15(13-25)33-24/h15-31H,2-14H2,1H3/t15-,16-,17-,18+,19-,20-,21-,22-,23-,24-/m1/s1
• InChI key: NLEBIOOXCVAHBD-QKMCSOCLSA-N

Description

General description

n-dodecyl-β-D-maltoside (DDM) is a sugar-based surfactant.

DDM is the most widely used detergent for the isolation and purification of GPCR′s. In addition, LacY likely favors a higher-energy intermediate periplasmic-open conformation in situ, but collapses to a lower-energy periplasmic-closed conformation in DDM after purification. It is interesting to note that the branched-chain maltoside detergents stabilize LacY in the membrane-embedded form.

Application

n-dodecyl-β-D-maltoside (DDM) has been used to solubilize mitochondrial extracts of fibroblasts to perform one-dimensional blue-native PAGE (BN-PAGE) analysis for assembled oxidative phosphorylation (OXPHOS) complexes.

Biochem/physiol Actions

n-dodecyl-β-D-maltoside (DDM) exhibits biocompatibility and biodegradability. It serves as a facilitator of electron transfer in order to decrease the oxidation potential of 3,4-ethylenedioxythiophene (EDOT). It can also increase the solubility of EDOT in aqueous solution.

Packaging

125 mL Amber Wide Mouth Glass Bottle with Screw Cap (850520P-25g)

20 mL Clear Glass Screw Cap Vial (850520P-1g)

30 mL Amber Wide Mouth Screw Cap Glass Bottle (850520P-5g)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable