810176P
Avanti
18:1-12:0 NBD PA
Avanti Polar Lipids 810176P, powder
Synonym(s):
1-oleoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphate (ammonium salt)
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All Photos(2)
About This Item
Empirical Formula (Hill Notation):
C39H68N5O11P
CAS Number:
Molecular Weight:
813.96
UNSPSC Code:
12352211
NACRES:
NA.25
Recommended Products
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810176P-1mg)
manufacturer/tradename
Avanti Polar Lipids 810176P
shipped in
dry ice
storage temp.
−20°C
General description
Phosphatidic acid (PA) is an anionic cellular glycerophospholipid constituting 1-4% of membrane lipids. It possesses a phosphomonoester polar head group and two long hydrophobic acyl chains. NBD PA is a fluorescently labelled lipid with the fluorophore, 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) at the sn-2 fatty acid of PA.
Application
18:1-12:0 NBD PA or 1-oleoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphate (ammonium salt) is suitable: for the in vitro enzyme activity assay of galactolipase, for NBD-PA and NBD phosphatidyl choline uptake assays, to measure lipid transfer specificity of Ups1 mutants
Biochem/physiol Actions
Phosphatidic acid (PA) is implicated in many membrane fusion and membrane fission events, such as fission of Golgi membranes. It is a bioactive lipid and a secondary messenger.
Packaging
5 mL Amber Glass Screw Cap Vial (810176P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
No data available
Flash Point(C)
No data available
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins
Miliara X, et al.
Nature Communications, 10(1), 1130-1130 (2019)
Anh H Ngo et al.
The New phytologist, 219(1), 163-175 (2018-04-15)
Phospholipases play crucial roles in plant membrane lipid homeostasis. Nonspecific phospholipase C (NPCs) establish a unique class of phospholipases found only in plants and certain bacteria. Here, we show that two previously uncharacterized NPC isoforms, NPC2 and NPC6, are required
John-Paul Andersen et al.
Molecular metabolism, 42, 101055-101055 (2020-08-02)
Cholesterol plays a pivotal role in mitochondrial steroidogenesis, membrane structure, and respiration. Mitochondrial membranes are intrinsically low in cholesterol content and therefore must be replenished with cholesterol from other subcellular membranes. However, the molecular mechanisms underlying mitochondrial cholesterol transport remains
Phosphatidic acid in membrane rearrangements
Zhukovsky MA, et al.
Febs Letters, 593(17), 2428-2451 (2019)
Mikhail A Zhukovsky et al.
FEBS letters, 593(17), 2428-2451 (2019-08-01)
Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique biophysical properties: a small headgroup; negative charge; and a phosphomonoester group. Upon interaction with lysine or arginine, PA charge increases from -1 to -2 and this change stabilizes protein-lipid
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