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B10102

Benzo[e]pyrene

Name: Benzo[<I>e</I>]pyrene
Brand: ALDRICH

98%

Synonym(s):

1,2-Benzpyrene, 4,5-Benzpyrene

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₂

CAS Number:

192-97-2

Molecular Weight:

252.31

Beilstein:

1911334

EC Number:

205-892-7

MDL number:

MFCD00003605

UNSPSC Code:

12352103

PubChem Substance ID:

24891539

NACRES:

NA.23

Assay

98%

form

crystals

mp

177-180 °C (lit.)

SMILES string

c1ccc2c(c1)c3cccc4ccc5cccc2c5c34

InChI

1S/C20H12/c1-2-8-16-15(7-1)17-9-3-5-13-11-12-14-6-4-10-18(16)20(14)19(13)17/h1-12H

InChI key

TXVHTIQJNYSSKO-UHFFFAOYSA-N

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General description

This polycyclic aromatic hydrocarbon is soluble in acetone. It is a non-carcinogenic benzopyrene isomer. Studies report its lack of immunosuppressive activity following in vivo and in vitro exposure.In nature, it is metabolized by strains of C. elegans to 3-benzo[e]Pyrene sulphate, 1-hydroxy-3-benzi[e]pyrenyl sulfate and bezo[e]Pyrene 3-O-ß-glucopyranoside.

Application

Used for studies of immune suppressive activity of bezo[e]Pyrene on antibody response to DNP-Ficoll and sheep erythrocytes and "dispersive liquid -liquid micro extraction” technique by extracting organic compounds from water samples.

Pictograms

GHS08,GHS09

Signal Word

Danger

Hazard Statements

H350,H410

Precautionary Statements

P201 - P273 - P308 + P313

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Direct suppression of in vitro antibody production by mouse spleen cells by the carcinogen benzo(a)pyrene but not by the noncarcinogenic congener benzo(e)pyrene.

K L White et al.

Cancer research, 44(8), 3388-3393 (1984-08-01)

The role of metabolic activation of benzo(a)pyrene B(a)P in mediating its suppression of humoral immune responsiveness of the female C57BL/6 X C3H F1 (hereafter called B6C3F1) mouse was addressed in these studies. The model was the in vitro antibody response

Determination of organic compounds in water using dispersive liquid-liquid microextraction.

Mohammad Rezaee et al.

Journal of chromatography. A, 1116(1-2), 1-9 (2006-04-01)

A new microextraction technique termed dispersive liquid-liquid microextraction (DLLME) was developed. DLLME is a very simple and rapid method for extraction and preconcentration of organic compounds from water samples. In this method, the appropriate mixture of extraction solvent (8.0 microL

Regulation of cytochrome P450 in cultured human colonic cells.

D W Rosenberg et al.

Archives of biochemistry and biophysics, 300(1), 186-192 (1993-01-01)

The consequences of altered cytochrome P450-dependent monooxygenase activities in colonic tissue are unknown. As an initial step toward elucidating underlying mechanisms that regulate cytochrome P450 levels in colonic epithelium, we have characterized CYP1A1(3) induction in cultured human colonic cells (Caco-2).

Identification and characterization of a specific autoantiphosphatidylinositol immune response during the time course of benzo(a)pyrene-induced malignant tumors in female Sprague-Dawley rats.

S Faiderbe et al.

Cancer research, 52(10), 2862-2865 (1992-05-15)

High levels of anti-phosphatidylinositol (PtdIns) autoantibodies (autoAb) have been previously described in sera of cancer patients and in plasma of dimethylbenzanthracene-treated female Sprague-Dawley rats. The presence of anti-PtdIns autoAb was tested in a model of highly malignant sarcomas induced by

Induction of CYP1A1 gene expression in mouse hepatoma cells by benzo[e]pyrene, a ligand of the 4S polycyclic hydrocarbon-binding protein.

K Sterling et al.

Toxicology and applied pharmacology, 128(1), 18-24 (1994-09-01)

Hepa 1c1c7 (WT), TAOc1BPrc1 (CI), and BPrc1 (CII) mouse hepatoma cells were exposed to benzo[e]pyrene (B[e]P) or benzo[a]pyrene (B[a]P). B[e]P induced activity of a rat CYP1A1 reporter gene construct (-3015 to +2545 bp) by 1.8- to 2-fold and 5-fold in

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