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Merck
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Key Documents

919926

Sigma-Aldrich

TissueFab® bioink 

Crosslinking solution, low endotoxin

Synonym(s):

Calcium chloride solution

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About This Item

UNSPSC Code:
12352201
NACRES:
NA.23

Quality Level

100

description

suitable for 3D bioprinting applications

sterility

sterile-filtered

form

viscous liquid

impurities

≤5 CFU/g Bioburden (Fungal)
≤5 CFU/g Bioburden (Total Aerobic)
<25 EU/mL Endotoxin

color

colorless to light yellow

particle size

0.1 μm

pH

6.5-7.5

application(s)

3D bioprinting

storage temp.

2-8°C

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Application

TissueFab® - crosslinking solution is 200 mM calcium chloride solution, it is a crosslinking agent for chemical crosslinking of bioinks that contain alginate. Alginate is a naturally occurring anionic polymer typically obtained from brown seaweed, and has been extensively in bioink formulations, due to its biocompatibility, structural similarity with extracellular matrix of living tissues, and mild gelation. The sodium salt of alginic acid can be crosslinked by exposing to the crosslinker solution containing divalent Ca2+ cation.

Packaging

5 x 10ml case pack

Legal Information

TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

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Kuen Yong Lee et al.
Progress in polymer science, 37(1), 106-126 (2011-11-30)
Alginate is a biomaterial that has found numerous applications in biomedical science and engineering due to its favorable properties, including biocompatibility and ease of gelation. Alginate hydrogels have been particularly attractive in wound healing, drug delivery, and tissue engineering applications

Articles

3D Bioprinting: Bioink Selection Guide

Bioinks can be 3D bioprinted into functional tissue constructs for drug screening, disease modeling, and in vitro transplantation. Choose the Bioinks and method for specific tissues engineering applications.

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