903981

2,3,7,8-Tetrafluorothianthrene-S-oxide

≥95%

• Synonym(s): 2,3,7,8-Tetrafluorothianthrene-5-oxide, Fluorinated sulfoxide-based thianthrene reagent, Ritter C-H functionalization linchpin, TFT S-oxide, TFT-reagent
• Empirical Formula (Hill Notation): C₁₂H₄F₄OS₂
• CAS Number: 2320491-72-1
• Molecular Weight: 304.28
• MDL number: MFCD32062467
• UNSPSC Code: 12352101
• NACRES: NA.22

Properties

• Assay: ≥95%
• form: solid
• mp: 253 °C
• functional group: fluoro; sulfoxide; thioether
• storage temp.: −20°C
• SMILES string: Fc1cc2c(cc1F)Sc3c(cc(c(c3)F)F)[S]2=O
• InChI: 1S/C12H4F4OS2/c13-5-1-9-11(3-7(5)15)19(17)12-4-8(16)6(14)2-10(12)18-9/h1-4H
• InChI key: FJNMYEBXFNFTBJ-UHFFFAOYSA-N

Description

Application

2,3,7,8-Tetrafluorothianthrene-S-oxide (TFT S-oxide) is a fluorinated sulfoxide-based thianthrene reagent for late-stage C-H functionalization. Developed by the Ritter Lab, C-H functionalization by thianthrenation with TFT S-oxide proceeds with >99% selectivity and furnishes functionalized arenes serving as synthetic linchpins for further participation in diverse transformations.
The nonfluorinated thianthrene S-oxide is also available as catalog# 903973 for all arenes more electron-rich than anisole.

Other Notes

Site-selective and versatile aromatic C-H functionalization by thianthrenation

Video: Site-selective C-H functionalization by thianthrenation

In the Pipeline: New Chemistry, Making New Things

Legal Information

Patent Application EP18204755.5
This product is manufactured pursuant to a license with Studiengesellschaft Kohle mbH

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable